Format

Send to:

Choose Destination

FAB1 1-phosphatidylinositol-3-phosphate 5-kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850574, updated on 5-Sep-2021

Summary

Gene symbol
FAB1
Gene description
1-phosphatidylinositol-3-phosphate 5-kinase
Primary source
SGD:S000001915
Locus tag
YFR019W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SVL7
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FAB1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (184502..191338)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Igd1p Neighboring gene uncharacterized protein Neighboring gene tRNA Neighboring gene Css2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of PAS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PAS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
1-phosphatidylinositol-3-phosphate 5-kinase
NP_116674.2
  • 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    184502..191338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179984.2NP_116674.2  TPA: 1-phosphatidylinositol-3-phosphate 5-kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116674.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34756
    Conserved Domains (4) summary
    PHA03255
    Location:64145
    PHA03255; BDLF3; Provisional
    COG5253
    Location:15972278
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:7971056
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cl28890
    Location:236296
    FYVE_like_SF; FYVE domain like superfamily
Support Center