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IOC3 Ioc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850567, updated on 3-Jun-2026
Official Symbol
IOC3
Official Full Name
Ioc3p
Primary source
SGD:S000001909
Locus tag
YFR013W
See related
AllianceGenome:SGD:S000001909; FungiDB:YFR013W; VEuPathDB:YFR013W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ATP hydrolysis activity; DNA binding activity; and nucleosome binding activity. Involved in sister chromatid cohesion. Part of Isw1a complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See IOC3 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (169922..172285)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Dcv1p Neighboring gene uncharacterized protein Neighboring gene calmodulin-dependent protein kinase CMK1 Neighboring gene glycogen (starch) synthase GSY1

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dynamic regulation of transcription factors by nucleosome remodeling. Li M, et al. Elife, 2015 Jun 5. PMID 26047462, Free PMC Article
  2. ATP-independent cooperative binding of yeast Isw1a to bare and nucleosomal DNA. De Cian A, et al. PLoS One, 2012. PMID 22359636, Free PMC Article
  3. Structure of the ISW1a complex bound to the dinucleosome. Li L, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38177688
  4. Structure and mechanism of the chromatin remodelling factor ISW1a. Yamada K, et al. Nature, 2011 Apr 28. PMID 21525927
  5. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Isw1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Isw1a complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Ioc3p
NP_116668.1
  • Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    169922..172285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179978.1 → NP_116668.1  Ioc3p

    See identical proteins and their annotated locations for NP_116668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTP4, P43596
    UniProtKB/TrEMBL
    G2WDF2
    Conserved Domains (1) summary
    pfam15612
    Location:365 → 411
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43596.1

Gene LinkOut

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