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RPN11 proteasome regulatory particle lid subunit RPN11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850554, updated on 22-Sep-2022

Summary

Gene symbol
RPN11
Gene description
proteasome regulatory particle lid subunit RPN11
Primary source
SGD:S000001900
Locus tag
YFR004W
See related
AllianceGenome:SGD:S000001900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MPR1
Summary
Enables metal-dependent deubiquitinase activity. Involved in several processes, including organelle fission; proteasome storage granule assembly; and proteolysis. Located in several cellular components, including cytosol; mitochondrion; and proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RPN11 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (153393..154313)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene linker nucleoporin NIC96 Neighboring gene type 1 protein phosphatase-activating protein YPI1 Neighboring gene mRNA splicing protein SAD1 Neighboring gene putative Xaa-Pro dipeptidase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the RPN11 gene: The RPN11 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables Lys63-specific deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal-dependent deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal-dependent deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peroxisome fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteasome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome storage granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
PubMed 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome regulatory particle lid subunit RPN11
NP_116659.1
  • Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    153393..154313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179969.1NP_116659.1  TPA: proteasome regulatory particle lid subunit RPN11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43588, Q8J0T5
    UniProtKB/TrEMBL
    A0A6A5PWR8, A0A6C1DT11, A7A242, B3LUL2, B5VI30, C7GYB0, C8Z7T7, G2WDE3, N1P4N6
    Conserved Domains (1) summary
    cd08069
    Location:22282
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5