YPI1 type 1 protein phosphatase-activating protein YPI1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YPI1
Official Full Name: type 1 protein phosphatase-activating protein YPI1
Primary source: SGD:S000001899
Locus tag: YFR003C
See related: AllianceGenome:SGD:S000001899; FungiDB:YFR003C; VEuPathDB:YFR003C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein phosphatase activator activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including glycogen metabolic process; mitotic spindle assembly checkpoint signaling; and regulation of protein localization to nucleus. Located in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Lithium influx is decreased by overexpression of Ypi1.
Title: Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin.
Ypi1 and Sds22 are positive regulators of the nuclear Glc7 activity that is required for mitosis.
Title: Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae.
Depletion of Ypi1 leads to alteration of nuclear localization of Glc7 and cell growth arrest in mid-mitosis with aberrant mitotic spindle.
Title: YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	NAS Non-traceable Author Statement more info	PubMed
involved_in glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 1 complex	IPI Inferred from Physical Interaction more info	PubMed

NP_116658.1

Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance