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BLM10 Blm10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850541, updated on 8-Oct-2024

Summary

Official Symbol
BLM10
Official Full Name
Blm10p
Primary source
SGD:S000001887
Locus tag
YFL007W
See related
AllianceGenome:SGD:S000001887; FungiDB:YFL007W; VEuPathDB:YFL007W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YFL006W
Summary
Enables peptidase activator activity and proteasome binding activity. Involved in several processes, including proteasome assembly; proteasome core complex import into nucleus; and proteasome storage granule assembly. Located in nucleus and proteasome storage granule. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See BLM10 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (123479..129910)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit CDC4 Neighboring gene cohesin subunit SMC1 Neighboring gene Rab family GTPase SEC4 Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

rep_origin

  • Loc: 127751-128071

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysine-acetylated histone binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proteasome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Blm10p
NP_116648.2
  • Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    123479..129910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179959.1NP_116648.2  TPA: Blm10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116648.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTM3, P43583, P43584
    UniProtKB/TrEMBL
    A7A232, G2WDD4
    Conserved Domains (3) summary
    pfam11919
    Location:20562142
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:5111030
    BLM10_mid; Proteasome-substrate-size regulator, mid region
    pfam16547
    Location:79159
    BLM10_N; Proteasome-substrate-size regulator, N-terminal