Format

Send to:

Choose Destination

MDJ1 Mdj1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850530, updated on 18-Nov-2018

Summary

Gene symbol
MDJ1
Gene description
Mdj1p
Primary source
SGD:S000001878
Locus tag
YFL016C
Gene type
protein coding
RNA name
Mdj1p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See MDJ1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (104701..106236, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMX2 Neighboring gene glucosamine 6-phosphate N-acetyltransferase Neighboring gene hypothetical protein Neighboring gene lipid-binding protein HSP12

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the MDJ1 gene: The MDJ1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
'de novo' protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Mdj1p
NP_116638.1
  • Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    104701..106236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179950.1NP_116638.1  TPA: Mdj1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116638.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35191
    Conserved Domains (4) summary
    cd10719
    Location:230292
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:293435
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:60456
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:61122
    DnaJ; DnaJ domain
Support Center