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MDJ1 Mdj1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850530, updated on 15-Mar-2026
Official Symbol
MDJ1
Official Full Name
Mdj1p
Primary source
SGD:S000001878
Locus tag
YFL016C
See related
AllianceGenome:SGD:S000001878; FungiDB:YFL016C; VEuPathDB:YFL016C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase activator activity and unfolded protein binding activity. Involved in several processes, including protein folding; protein quality control for misfolded or incompletely synthesized proteins; and response to heat. Located in mitochondrial matrix. Orthologous to human DNAJA3 (DnaJ heat shock protein family (Hsp40) member A3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See MDJ1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (104701..106236, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMX2 Neighboring gene glucosamine 6-phosphate N-acetyltransferase Neighboring gene uncharacterized protein Neighboring gene lipid-binding protein HSP12

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding. Rowley N, et al. Cell, 1994 Apr 22. PMID 8168133
  2. Nucleoid localization of Hsp40 Mdj1 is important for its function in maintenance of mitochondrial DNA. Ciesielski GL, et al. Biochim Biophys Acta, 2013 Oct. PMID 23688635, Free PMC Article
  3. Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue. Deloche O, et al. J Biol Chem, 1997 Nov 7. PMID 9353316
  4. Understanding the Mechanism of Thermotolerance Distinct From Heat Shock Response Through Proteomic Analysis of Industrial Strains of Saccharomyces cerevisiae. Shui W, et al. Mol Cell Proteomics, 2015 Jul. PMID 25926660, Free PMC Article
  5. Role of the mitochondrial DnaJ homologue, Mdj1p, in the prevention of heat-induced protein aggregation. Prip-Buus C, et al. FEBS Lett, 1996 Feb 12. PMID 8603724

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein refolding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Mdj1p
NP_116638.1
  • Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    104701..106236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179950.1 → NP_116638.1  Mdj1p

    See identical proteins and their annotated locations for NP_116638.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTL4, P35191
    UniProtKB/TrEMBL
    A7A223, G2WDC5, N1P361
    Conserved Domains (1) summary
    COG0484
    Location:60 → 456
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35191.1

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