GNA1 glucosamine 6-phosphate N-acetyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GNA1
Gene description: glucosamine 6-phosphate N-acetyltransferase
Primary source: SGD:S000001877
Locus tag: YFL017C
See related: AllianceGenome:SGD:S000001877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAT1
Summary: Enables glucosamine 6-phosphate N-acetyltransferase activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer and keratosis follicularis spinulosa decalvans. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GNA1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (103983..104462, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the GNA1 gene: The GNA1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, and A.thaliana.
Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables glucosamine 6-phosphate N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glucosamine 6-phosphate N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucosamine 6-phosphate N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in UDP-N-acetylglucosamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: glucosamine 6-phosphate N-acetyltransferase

NP_116637.1

EC 2.3.1.4

Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

103983..104462 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179949.1 → NP_116637.1 TPA: glucosamine 6-phosphate N-acetyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116637.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTL3, P43577

UniProtKB/TrEMBL

A0A6A5PWK9, G2WDC4, N1P4L7

Conserved Domains (1) summary

cl17182
Location:5 → 155

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate