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MOB2 Mob2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850508, updated on 18-Sep-2024

Summary

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Official Symbol
MOB2
Official Full Name
Mob2p
Primary source
SGD:S000001859
Locus tag
YFL034C-B
See related
AllianceGenome:SGD:S000001859; FungiDB:YFL034C-B; VEuPathDB:YFL034C-B
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YFL035C; YFL035C-A
Summary
Enables protein kinase activator activity. Involved in several processes, including budding cell apical bud growth; positive regulation of protein phosphorylation; and septum digestion after cytokinesis. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MOB2 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
2
Sequence:
Chromosome: VI; NC_001138.5 (63016..63993, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase Neighboring gene ribosomal 60S subunit protein L22B Neighboring gene Mil1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Mrkobrada S, et al. J Mol Biol, 2006 Sep 22. PMID 16934835
  2. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. Weiss EL, et al. J Cell Biol, 2002 Sep 2. PMID 12196508, Free PMC Article
  3. Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface. Parker BW, et al. Biochemistry, 2020 May 5. PMID 32250593, Free PMC Article
  4. The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Gógl G, et al. PLoS Biol, 2015 May. PMID 25966461, Free PMC Article
  5. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Luca FC, et al. Mol Biol Cell, 1998 Jan. PMID 9436989, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in budding cell apical bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in budding cell apical bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septum digestion after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mob2p
NP_116618.1
  • Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    63016..63993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179931.1 → NP_116618.1  TPA: Mob2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116618.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTJ5, P43563
    UniProtKB/TrEMBL
    A7A204, B3LUH6, C8Z7P7, N1P330
    Conserved Domains (1) summary
    pfam03637
    Location:102 → 271
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43563.2

Gene LinkOut

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