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YPT1 Rab family GTPase YPT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850505, updated on 2-Nov-2024

Summary

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Official Symbol
YPT1
Official Full Name
Rab family GTPase YPT1
Primary source
SGD:S000001856
Locus tag
YFL038C
See related
AllianceGenome:SGD:S000001856; FungiDB:YFL038C; VEuPathDB:YFL038C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity and SNARE binding activity. Involved in several processes, including Golgi vesicle transport; SNARE complex assembly; and macroautophagy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum membrane; and phagophore assembly site. Used to study colorectal cancer. Orthologous to several human genes including RAB1B (RAB1B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YPT1 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (55366..55986, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene actin Neighboring gene beta-tubulin Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Testing the Phenotypic Effects of a Rab Chimera that Resolves Exchange Factor Specificity from Effector Specificity. Yuan H, et al. Methods Mol Biol, 2021. PMID 34453710
  2. Characterization of secretory genes ypt1/yptA and nsf1/nsfA from two filamentous fungi: induction of secretory pathway genes of Trichoderma reesei under secretion stress conditions. Saloheimo M, et al. Appl Environ Microbiol, 2004 Jan. PMID 14711675, Free PMC Article
  3. TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei. Dhir V, et al. Mol Biochem Parasitol, 2004 Oct. PMID 15383296
  4. Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport. Jones S, et al. J Cell Biol, 1995 Sep. PMID 7657691, Free PMC Article
  5. The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway. Jedd G, et al. J Cell Biol, 1995 Nov. PMID 7593181, Free PMC Article

See all (208) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
    Title: TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
  2. The Sequential Recruitments of Rab-GTPase Ypt1p and the NNS Complex onto pre-HAC1 mRNA Promote Its Nuclear Degradation in Baker's Yeast.
    Title: The Sequential Recruitments of Rab-GTPase Ypt1p and the NNS Complex onto pre-HAC1 mRNA Promote Its Nuclear Degradation in Baker's Yeast.
  3. Structural basis of TRAPPIII-mediated Rab1 activation.
    Title: Structural basis of TRAPPIII-mediated Rab1 activation.
  4. ypt1-G80D mutant is highly sensitive to heat-shock, due to a deficiency in the chaperone function of Ypt1pG80D.
    Title: Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D.
  5. TRAPPIII and Ypt1 control membrane trafficking events under normal growth conditions and during autophagy.
    Title: The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway.
  6. Since these there proteinases belong to the CPY pathway, YPT1 is even believed to up-regulate this trafficking pathway in yeast cells. Future studies, however, should be carried out to discover the mechanisms that allow YPT1 to recruit these proteins into yeast vacuoles
    Title: Effect of GTP-binding protein (YPT1 protein) on the enhanced yeast vacuolar activity.
  7. that changes in Ypt1 and Ypt31 activity affect Golgi cisternal progression, early-to-transitional and transitional-to-late, respectively
    Title: Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases.
  8. Ypt1 binds and activates Hrr25 to spatially regulate its kinase activity.
    Title: Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy.
  9. Finally, three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole
    Title: A Role for Macro-ER-Phagy in ER Quality Control.
  10. results suggest that Ypt1p is involved in the cellular protection process under heat stress conditions
    Title: Stress-driven structural and functional switching of Ypt1p from a GTPase to a molecular chaperone mediates thermo tolerance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi vesicle budding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SNARE complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SNARE complex disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reticulophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rab family GTPase YPT1
NP_116615.1
  • Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    55366..55986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179928.1 → NP_116615.1  TPA: Rab family GTPase YPT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_116615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTJ2, P01123
    UniProtKB/TrEMBL
    A7A201, B3LUH3, B5VHY9, C7GY75, C8Z7P4, G2WDA3, N1P4U5
    Conserved Domains (1) summary
    cd01869
    Location:7 → 172
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01123.2

Gene LinkOut

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