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MSH3 mismatch repair protein MSH3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850454, updated on 5-May-2019

Summary

Gene symbol
MSH3
Gene description
mismatch repair protein MSH3
Primary source
SGD:S000000688
Locus tag
YCR092C
Gene type
protein coding
RNA name
mismatch repair protein MSH3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See MSH3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (276764..279820, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene putative serine/threonine protein kinase KIN82 Neighboring gene CCR4-NOT core subunit CDC39 Neighboring gene aminophospholipid translocase regulatory protein CDC50

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA insertion or deletion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA insertion or deletion binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to Y-form DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-strand/single-strand DNA junction binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to heteroduplex DNA loop binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to mismatched DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
maintenance of DNA repeat elements IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mismatch repair IEA
Inferred from Electronic Annotation
more info
 
mismatch repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of nonhomologous ends IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of nonhomologous ends IGI
Inferred from Genetic Interaction
more info
PubMed 
removal of nonhomologous ends IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
replication fork arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
MutSbeta complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MutSbeta complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytoplasm HDA PubMed 
mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mismatch repair protein MSH3
NP_010016.2
  • Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    276764..279820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178798.1NP_010016.2  TPA: mismatch repair protein MSH3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010016.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25336
    Conserved Domains (6) summary
    cd03287
    Location:755971
    ABC_MSH3_euk; ATP-binding cassette domain of eukaryotic MutS3 homolog
    COG0249
    Location:1271015
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:133259
    MutS_I; MutS domain I
    pfam05188
    Location:276406
    MutS_II; MutS domain II
    pfam05190
    Location:606695
    MutS_IV; MutS family domain IV
    pfam05192
    Location:423527
    MutS_III; MutS domain III
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