HCM1 Hcm1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: HCM1
Official Full Name: Hcm1p
Primary source: SGD:S000000661
Locus tag: YCR065W
See related: AllianceGenome:SGD:S000000661; FungiDB:YCR065W; VEuPathDB:YCR065W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity and mitochondrial transcription factor activity. Involved in several processes, including cellular response to oxidative stress; regulation of DNA-templated transcription; and spindle pole body organization. Located in chromatin; cytoplasm; and nucleus. Is active in mitochondrion. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; primary ciliary dyskinesia 43; primary ovarian insufficiency 3; and type 2 diabetes mellitus. Orthologous to several human genes including FOXA2 (forkhead box A2); FOXD2 (forkhead box D2); and FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1.
Title: Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1.
Mitochondrial Localization of the Yeast Forkhead Factor Hcm1.
Title: Mitochondrial Localization of the Yeast Forkhead Factor Hcm1.
A mutational analysis revealed that phosphorylation of Hcm1 at S61, S65, and S66 is required for the proper onset of the cell wall integrity checkpoint by regulating the timely decrease in its protein level.
Title: The Late S-Phase Transcription Factor Hcm1 Is Regulated through Phosphorylation by the Cell Wall Integrity Checkpoint.
HCM1 is a key regulator of life span, through a mechanism independent of calorie restriction.
Title: The yeast forkhead HCM1 controls life span independent of calorie restriction.
When nutrient levels decrease, Snf1 phosphorylates Hcm1.
Title: The FOX transcription factor Hcm1 regulates oxidative metabolism in response to early nutrient limitation in yeast. Role of Snf1 and Tor1/Sch9 kinases.
Study identifies a late S-phase-specific promoter element, the binding site for the forkhead protein Hcm1, which is required for its cell cycle-specific activity.
Title: The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitochondrial transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transcription	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle pole body organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_009991.2

Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources, NAD synthesis, oxidative stress resistance; regulated by cell wall integrity checkpoint; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4