THR4 threonine synthase THR4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THR4
Official Full Name: threonine synthase THR4
Primary source: SGD:S000000649
Locus tag: YCR053W
See related: AllianceGenome:SGD:S000000649; FungiDB:YCR053W; VEuPathDB:YCR053W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables threonine synthase activity. Involved in threonine biosynthetic process. Located in cytoplasm and nucleus. Orthologous to several human genes including THNSL2 (threonine synthase like 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See THR4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (216697..218241)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3695 (e-PCR)
- UniSTS:474273

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables threonine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine synthase activity	IEA Inferred from Electronic Annotation more info
enables threonine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables threonine synthase activity	RCA inferred from Reviewed Computational Analysis more info

Process	Evidence Code	Pubs
involved_in L-homoserine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-threonine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-threonine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-threonine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-threonine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-threonine metabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: threonine synthase THR4

NP_009982.1

EC 4.2.3.1

Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

216697..218241

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178767.1 → NP_009982.1 threonine synthase THR4

See identical proteins and their annotated locations for NP_009982.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR61, E9P943, P16120

UniProtKB/TrEMBL

B3LUB6

Conserved Domains (1) summary

cd01560
Location:8 → 479

Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...