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ELO2 fatty acid elongase ELO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850400, updated on 14-Nov-2024

Summary

Official Symbol
ELO2
Official Full Name
fatty acid elongase ELO2
Primary source
SGD:S000000630
Locus tag
YCR034W
See related
AllianceGenome:SGD:S000000630; FungiDB:YCR034W; VEuPathDB:YCR034W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FEN1; GNS1; VBM2
Summary
Enables fatty acid elongase activity. Involved in fatty acid biosynthetic process; late endosome to vacuole transport via multivesicular body sorting pathway; and sphingolipid biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 38. Orthologous to several human genes including ELOVL2 (ELOVL fatty acid elongase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ELO2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (190592..191635)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Bph1p Neighboring gene Snt1p Neighboring gene exosome non-catalytic core subunit RRP43 Neighboring gene putative ribokinase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid elongase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fatty acid elongase ELO2
NP_009963.1
  • Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    190592..191635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178748.1NP_009963.1  TPA: fatty acid elongase ELO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009963.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR44, P25358
    UniProtKB/TrEMBL
    A6ZTL5, B3LUA3, B5VEX8, C7GQ21, C8Z4C4, G2WA52, N1P9A9
    Conserved Domains (1) summary
    pfam01151
    Location:64307
    ELO; GNS1/SUR4 family