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FEN2 Fen2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850394, updated on 24-Jan-2026
Official Symbol
FEN2
Official Full Name
Fen2p
Primary source
SGD:S000000623
Locus tag
YCR028C
See related
AllianceGenome:SGD:S000000623; FungiDB:YCR028C; VEuPathDB:YCR028C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pantothenate transmembrane transporter activity. Involved in endocytosis and pantothenate transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See FEN2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (170886..172424, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative GTPase RHB1 Neighboring gene tRNA-Gln Neighboring gene Rim1p Neighboring gene Syp1p

Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. FEN2: a gene implicated in the catabolite repression-mediated regulation of ergosterol biosynthesis in yeast. Marcireau C, et al. Yeast, 1996 May. PMID 8771708
  2. The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373490
  3. Nucleotide sequence of 9.2 kb left of CRY1 on yeast chromosome III from strain AB972: evidence for a Ty insertion and functional analysis of open reading frame YCR28. Agostoni Carbone ML, et al. Yeast, 1992 Sep. PMID 1332309
  4. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. Augagneur Y, et al. J Biol Chem, 2013 Jul 12. PMID 23729665, Free PMC Article
  5. Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373489

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables pantothenate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantothenate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pantothenate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
Fen2p
NP_009957.1
  • Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    170886..172424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178743.1 → NP_009957.1  Fen2p

    See identical proteins and their annotated locations for NP_009957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR38, P25621
    UniProtKB/TrEMBL
    A6ZTK9, B3LU99, B5VEX5, C7GQ16, G2WA46, N1PAQ3
    Conserved Domains (1) summary
    cd17327
    Location:32 → 450
    MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25621.1

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