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CIT2 citrate (Si)-synthase CIT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850361, updated on 7-Oct-2018

Summary

Gene symbol
CIT2
Gene description
citrate (Si)-synthase CIT2
Primary source
SGD:S000000598
Locus tag
YCR005C
Gene type
protein coding
RNA name
citrate (Si)-synthase CIT2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See CIT2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (120946..122328, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL32 Neighboring gene flavodoxin-like fold family protein Neighboring gene hypothetical protein Neighboring gene tRNA

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CIT2 gene: The CIT2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
citrate (Si)-synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
citrate (Si)-synthase activity IEA
Inferred from Electronic Annotation
more info
 
citrate (Si)-synthase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
citrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
citrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
glutamate biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
glyoxylate cycle TAS
Traceable Author Statement
more info
PubMed 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
citrate (Si)-synthase CIT2
NP_009931.1
  • Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    120946..122328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178718.1NP_009931.1  TPA: citrate (Si)-synthase CIT2 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08679
    Conserved Domains (1) summary
    cl00416
    Location:26452
    CS_ACL-C_CCL; Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A ...
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