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SGF29 Sgf29p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850347, updated on 23-Apr-2026
Official Symbol
SGF29
Official Full Name
Sgf29p
Primary source
SGD:S000000516
Locus tag
YCL010C
See related
AllianceGenome:SGD:S000000516; FungiDB:YCL010C; VEuPathDB:YCL010C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables methylated histone binding activity. Involved in SAGA complex localization to transcription regulatory region; positive regulation of transcription by RNA polymerase II; and protein localization. Part of ADA complex and SAGA complex. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human SGF29 (SAGA complex associated factor 29). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See SGF29 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (103571..104350, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene single-stranded telomeric DNA-binding/mRNA-binding protein Neighboring gene acetolactate synthase regulatory subunit Neighboring gene ubiquitin-binding ESCRT-I subunit protein STP22

Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae. Li J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693663, Free PMC Article
  2. Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo. Shukla A, et al. Biochemistry, 2012 Jan 17. PMID 22224423, Free PMC Article
  3. Synthetic protein interactions reveal a functional map of the cell. Berry LK, et al. Elife, 2016 Apr 21. PMID 27098839, Free PMC Article
  4. The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Lim S, et al. Mech Ageing Dev, 2021 Jun. PMID 33831401
  5. The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae. Hickman MJ, et al. Genetics, 2011 Jun. PMID 21467572, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tandem tudor domain at the C-terminus of Sgf29 was crystallized using the hanging-drop vapour-diffusion method and the crystals diffracted to 1.92 A resolution
    Title: Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone H3K4me3 reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in SAGA complex localization to transcription regulatory region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ADA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of ADA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
Sgf29p
NP_009917.1
  • Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    103571..104350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178659.1 → NP_009917.1  Sgf29p

    See identical proteins and their annotated locations for NP_009917.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR02, P25554, P87008
    UniProtKB/TrEMBL
    B3LU65, B5VEU2, N1P677
    Conserved Domains (1) summary
    pfam07039
    Location:127 → 250
    DUF1325; SGF29 tudor-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25554.2

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