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LEU2 3-isopropylmalate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850342, updated on 8-Jun-2019

Summary

Gene symbol
LEU2
Gene description
3-isopropylmalate dehydrogenase
Primary source
SGD:S000000523
Locus tag
YCL018W
Gene type
protein coding
RNA name
3-isopropylmalate dehydrogenase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See LEU2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (91324..92418)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA Neighboring gene Nfs1p Neighboring gene Dcc1p

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the LEU2 gene: The LEU2 gene is conserved in S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.

Gene Ontology Provided by GO

Function Evidence Code Pubs
3-isopropylmalate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3-isopropylmalate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
3-isopropylmalate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
3-isopropylmalate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glyoxylate cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-isopropylmalate dehydrogenase
NP_009911.2
  • Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    91324..92418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178665.1NP_009911.2  TPA: 3-isopropylmalate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009911.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P04173
    Conserved Domains (1) summary
    TIGR00169
    Location:6359
    leuB; 3-isopropylmalate dehydrogenase
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