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KCC4 serine/threonine protein kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850334, updated on 19-Nov-2025
Official Symbol
KCC4
Official Full Name
serine/threonine protein kinase
Primary source
SGD:S000000529
Locus tag
YCL024W
See related
AllianceGenome:SGD:S000000529; FungiDB:YCL024W; VEuPathDB:YCL024W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activity. Involved in budding cell bud growth; mitotic morphogenesis checkpoint signaling; and septin ring assembly. Located in cellular bud neck septin collar; incipient cellular bud site; and septin ring. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See KCC4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (79162..82275)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene type II nitroreductase Neighboring gene amino acid transporter AGP1 Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast. Asano S, et al. J Biol Chem, 2006 Sep 15. PMID 16861226
  2. Role of the septin ring in the asymmetric localization of proteins at the mother-bud neck in Saccharomyces cerevisiae. Kozubowski L, et al. Mol Biol Cell, 2005 Aug. PMID 15901837, Free PMC Article
  3. Kcc4 associates with septin proteins of Saccharomyces cerevisiae. Okuzaki D, et al. FEBS Lett, 2001 Feb 2. PMID 11165249
  4. The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Okuzaki D, et al. Genes Genet Syst, 2003 Apr. PMID 12773812
  5. Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function. Longtine MS, et al. J Cell Biol, 1998 Nov 2. PMID 9813093, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in budding cell bud growth IEA
Inferred from Electronic Annotation
more info
  
involved_in budding cell bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic morphogenesis checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic morphogenesis checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in septin ring assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck septin collar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck septin structure IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage apparatus septin structure IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septin ring IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine protein kinase
NP_009907.2
  • Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    79162..82275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178670.1 → NP_009907.2  TPA: serine/threonine protein kinase

    See identical proteins and their annotated locations for NP_009907.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ2, P25389, P87005, Q8NKJ8
    UniProtKB/TrEMBL
    C8Z466, N1P667
    Conserved Domains (2) summary
    cd12194
    Location:920 → 1034
    Kcc4p_like_C; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins
    cl21453
    Location:19 → 285
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25389.3

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