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AGP1 amino acid transporter AGP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850333, updated on 24-Jan-2026
Official Symbol
AGP1
Official Full Name
amino acid transporter AGP1
Primary source
SGD:S000000530
Locus tag
YCL025C
See related
AllianceGenome:SGD:S000000530; FungiDB:YCL025C; VEuPathDB:YCL025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WAP1; YCC5
Summary
Enables L-proline transmembrane transporter activity. Involved in serine import across plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to several human genes including SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See AGP1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (76018..77919, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative nitroreductase Neighboring gene type II nitroreductase Neighboring gene serine/threonine protein kinase Neighboring gene tRNA-Glu

Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
    Title: Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
  2. Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the Plasma Membrane , and have features that discriminate them from the termini of organellar amino acid transporters
    Title: A Plasma Membrane Association Module in Yeast Amino Acid Transporters.
  3. Ubiquitination sites of Agp1 significantly affect the nitrogen utilization.
    Title: [Effects of transporter Agp1p ubiquitination on nitrogen utilization in Saccharomyces cerevisiae].
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-phenylalanine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-proline transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in serine import across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in serine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
amino acid transporter AGP1
NP_009905.3
  • Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    76018..77919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178671.1 → NP_009905.3  amino acid transporter AGP1

    See identical proteins and their annotated locations for NP_009905.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQZ1, P25376
    UniProtKB/TrEMBL
    B3LU57, C7GSY2, N1P7S5
    Conserved Domains (1) summary
    TIGR00913
    Location:117 → 597
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25376.3

Gene LinkOut

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