RNQ1 prion domain-containing protein RNQ1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: RNQ1
Official Full Name: prion domain-containing protein RNQ1
Primary source: SGD:S000000533
Locus tag: YCL028W
See related: AllianceGenome:SGD:S000000533; FungiDB:YCL028W; VEuPathDB:YCL028W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Located in cytosol. [provided by Alliance of Genome Resources, May 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RNQ1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (70150..71367)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mapping of Prion Structures in the Yeast Rnq1.
Title: Mapping of Prion Structures in the Yeast Rnq1.
concluded that slow decoding of particular codons induces defects in protein homeostasis that interfere with key steps in cytokinesis and nuclear segregation
Title: Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.
results show that the presence of Rnq1p in the cell significantly decreases the loss of [PSI;(+)] prion, which is caused by a double mutation in SUP35 (Q61K, Q62K substitutions in the Sup35 protein).
Title: [Rnq1 protein protects [PSI^(+)] prion from effect of the PNM mutation].
Taking into account the earlier reports of the beneficial effect of expression of N-wt-Htt on the aggregation of mutant huntingtin, the function of wild-type huntingtin as an inhibitor of protein aggregation in the cell needs to be explored.
Title: Cellular toxicity of yeast prion protein Rnq1 can be modulated by N-terminal wild type huntingtin.
the presence of [SWI+] can affect the interactions between Sup35 and Rnq1 during [PSI+] initiation and maturation process
Title: Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+].
Study describes a spectrum of prion variants occurring naturally in wild yeast. all of the [RNQ+] variants characterized were efficient inducers of [PSI+], but differed in the subset of [PSI+] variants that formed and [RNQ+] structures can be modified after inducing, or interacting with, [PSI+] and in some cases, this interaction resulted in the loss of [RNQ+].
Title: Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities.
Polymorphism of RNQ1 was selected to protect cells from detrimental effects of the [PIN+] prion.
Title: Sex, prions, and plasmids in yeast.
Data indicate that the majority of mutated residues are mapped to the surface, and on one side, of contiguous alpha-helices of the nonprion domain of Rnq1, suggesting its involvement in interactions with a prion or a factor necessary for prion developmentt
Title: [PSI(+)] aggregate enlargement in rnq1 nonprion domain mutants, leading to a loss of prion in yeast.
Data suggest that transient Hsp104 overproduction enhances prion generation through persistent effects on Rnq1 amyloid, as well as by disassembly of amorphous Ure2 aggregates, driving the aggregation toward the amyloid pathway.
Title: Molecular chaperone Hsp104 can promote yeast prion generation.
polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis
Title: Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info