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HIS4 trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850327, updated on 10-Oct-2019

Summary

Gene symbol
HIS4
Gene description
trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
Primary source
SGD:S000000535
Locus tag
YCL030C
Gene type
protein coding
RNA name
trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See HIS4 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (65934..68333, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Ste50p Neighboring gene Rrp7p Neighboring gene Bik1p Neighboring gene prion domain-containing protein RNQ1

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the HIS4 gene: The HIS4 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
histidinol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histidinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
histidinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
histidinol dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoribosyl-AMP cyclohydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoribosyl-AMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoribosyl-AMP cyclohydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphoribosyl-ATP diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoribosyl-ATP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoribosyl-ATP diphosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
NP_009900.2
  • Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    65934..68333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178675.1NP_009900.2  TPA: trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009900.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P00815
    Conserved Domains (4) summary
    cd11546
    Location:244327
    NTP-PPase_His4; Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in His4-like fungal histidine biosynthesis trifunctional proteins and their homologs
    COG0139
    Location:133243
    HisI1; Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]
    TIGR00069
    Location:388787
    hisD; histidinol dehydrogenase
    pfam00815
    Location:374787
    Histidinol_dh; Histidinol dehydrogenase
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