PKP4 plakophilin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PKP4provided by HGNC
Official Full Name: plakophilin 4provided by HGNC
Primary source: HGNC:HGNC:9026
See related: Ensembl:ENSG00000144283 MIM:604276; Vega:OTTHUMG00000153969
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p0071
Summary: Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Expression: Ubiquitous expression in kidney (RPKM 22.9), thyroid (RPKM 17.0) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 2q24.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	2	NC_000002.12 (158456880..158681429)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (159313476..159537941)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules.
Title: The armadillo protein p0071 controls KIF3 motor transport.
Data show that patients with both abnormal expression of p0071 and E-cadherin had a statistically significant shorter survival than the patients without both abnormal expression.
Title: p0071 interacts with E-cadherin in the cytoplasm so as to promote the invasion and metastasis of non-small cell lung cancer.
p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment.
Title: The armadillo protein p0071 is involved in Rab11-dependent recycling.
This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review]
Title: p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization.
Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling.
Title: Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis.
These data support a model in which dysregulation of the FLCN-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA signaling.
Title: Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed.
Title: Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules.
Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis.
Title: Targeting of p0071 to the midbody depends on KIF3.
Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia.
Title: Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell-type marker.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
integrase	gag-pol	Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that PKP4 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with PKP4	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
Keratinization, organism-specific biosystem (from REACTOME)
Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-63463 (e-PCR)
- UniSTS:20228

STS-AA021522 (e-PCR)
- UniSTS:73488

D2S2505 (e-PCR)
- UniSTS:65043

DZIP1 (e-PCR)
- UniSTS:505370

RH92183 (e-PCR)
- UniSTS:89628

D2S1320 (e-PCR)
- UniSTS:71766

SHGC-144007 (e-PCR)
- UniSTS:172129

D2S1991 (e-PCR)
- UniSTS:12134

SHGC-24308 (e-PCR)
- UniSTS:12135

G20235 (e-PCR)
- UniSTS:897

A005B01 (e-PCR)
- UniSTS:898

D2S2681 (e-PCR)
- UniSTS:17026

G63204 (e-PCR)
- UniSTS:140178

A009U35 (e-PCR)
- UniSTS:81815

SHGC-85218 (e-PCR)
- UniSTS:104355

D2S1649E (e-PCR)
- UniSTS:150699

SHGC-58134 (e-PCR)
- UniSTS:64950

G32853 (e-PCR)
- UniSTS:117432

RH45241 (e-PCR)
- UniSTS:49852

SHGC-56770 (e-PCR)
- UniSTS:59068

SHGC-101671 (e-PCR)
- UniSTS:183239

D2S1986 (e-PCR)
- UniSTS:79584

SHGC-82440 (e-PCR)
- UniSTS:104417

D2S1623E (e-PCR)
- UniSTS:13547

SHGC-133038 (e-PCR)
- UniSTS:170987

SHGC-81249 (e-PCR)
- UniSTS:102382

WI-22189 (e-PCR)
- UniSTS:29431

Homology

Homologs of the PKP4 gene: The PKP4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 238 organisms have orthologs with human gene PKP4
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cadherin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell-cell adhesion	IEA Inferred from Electronic Annotation more info
cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell-cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
cornification	TAS Traceable Author Statement more info
keratinization	TAS Traceable Author Statement more info
positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cell junction	IDA Inferred from Direct Assay more info
cell-cell adherens junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cornified envelope	TAS Traceable Author Statement more info
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
desmosome	IDA Inferred from Direct Assay more info	PubMed
midbody	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with midbody	IDA Inferred from Direct Assay more info	PubMed
mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
spindle midzone	IDA Inferred from Direct Assay more info	PubMed
spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plakophilin-4

Names: catenin 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005476.2 → NP_001005476.1 plakophilin-4 isoform b

See identical proteins and their annotated locations for NP_001005476.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC005042, BC034473, BC050308, BQ017486, DB473248, X81889

Consensus CDS

CCDS33306.1

UniProtKB/Swiss-Prot

Q99569

Related

ENSP00000374407.3, OTTHUMP00000204742, ENST00000389757.7, OTTHUMT00000333249

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
NM_001304969.1 → NP_001291898.1 plakophilin-4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction at an internal exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform a.

Source sequence(s)

AC005042, BC034473, BC050308, BQ017486, DB473248, X81889

UniProtKB/Swiss-Prot

Q99569

Related

ENSP00000486320.1, ENST00000628904.2

Conserved Domains (2) summary

cd00020
Location:521 → 643

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:529 → 554

ARM; armadillo repeat [structural motif]
NM_001304970.1 → NP_001291899.1 plakophilin-4 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two alternate splice sites at internal exons compared to variant 1. These differences result in predicted translation initiation at a downstream in-frame start site through ribosomal re-initiation or leaky scanning. The encoded isoform (d) is shorter compared to isoform 1.

Source sequence(s)

AC005042, BC034473, BC048013, BC050308, BQ017486, DB473248, X81889

UniProtKB/Swiss-Prot

Q99569

Conserved Domains (2) summary

cd00020
Location:179 → 301

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:187 → 212

ARM; armadillo repeat [structural motif]
NM_001304971.1 → NP_001291900.1 plakophilin-4 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC005042, BC034473, DB473248

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
NM_003628.4 → NP_003619.2 plakophilin-4 isoform a

See identical proteins and their annotated locations for NP_003619.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC005042, BC034473, BC050308, BQ017486, DB473248, X81889

Consensus CDS

CCDS33305.1

UniProtKB/Swiss-Prot

Q99569

Related

ENSP00000374409.3, OTTHUMP00000204743, ENST00000389759.7, OTTHUMT00000333250

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p12 Primary Assembly

Range

158456880..158681429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011512017.1 → XP_011510319.1 plakophilin-4 isoform X3

See identical proteins and their annotated locations for XP_011510319.1

Conserved Domains (2) summary

cd00020
Location:520 → 642

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:528 → 553

ARM; armadillo repeat [structural motif]
XM_017005126.1 → XP_016860615.1 plakophilin-4 isoform X6
XM_011512019.1 → XP_011510321.1 plakophilin-4 isoform X4

Conserved Domains (2) summary

cd00020
Location:519 → 641

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:527 → 552

ARM; armadillo repeat [structural motif]
XM_011512020.3 → XP_011510322.1 plakophilin-4 isoform X7

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
XM_011512021.3 → XP_011510323.1 plakophilin-4 isoform X8

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
XM_017005125.2 → XP_016860614.1 plakophilin-4 isoform X5
XM_017005128.2 → XP_016860617.1 plakophilin-4 isoform X9
XM_011512026.3 → XP_011510328.1 plakophilin-4 isoform X15

Conserved Domains (3) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam13646
Location:559 → 633

HEAT_2; HEAT repeats

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
XM_011512016.2 → XP_011510318.1 plakophilin-4 isoform X1

See identical proteins and their annotated locations for XP_011510318.1

UniProtKB/Swiss-Prot

Q99569

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
XM_017005127.2 → XP_016860616.1 plakophilin-4 isoform X8

Conserved Domains (2) summary

cd00020
Location:522 → 644

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:530 → 555

ARM; armadillo repeat [structural motif]
XM_017005122.2 → XP_016860611.1 plakophilin-4 isoform X2

Conserved Domains (2) summary

cd00020
Location:521 → 643

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:529 → 554

ARM; armadillo repeat [structural motif]
XM_011512018.2 → XP_011510320.1 plakophilin-4 isoform X3

See identical proteins and their annotated locations for XP_011510320.1

Conserved Domains (2) summary

cd00020
Location:520 → 642

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:528 → 553

ARM; armadillo repeat [structural motif]
XM_017005124.2 → XP_016860613.1 plakophilin-4 isoform X4

Conserved Domains (2) summary

cd00020
Location:519 → 641

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:527 → 552

ARM; armadillo repeat [structural motif]
XM_017005134.2 → XP_016860623.1 plakophilin-4 isoform X16
XM_017005133.2 → XP_016860622.1 plakophilin-4 isoform X16
XM_011512022.2 → XP_011510324.1 plakophilin-4 isoform X10

See identical proteins and their annotated locations for XP_011510324.1

Conserved Domains (2) summary

cd00020
Location:374 → 496

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:382 → 407

ARM; armadillo repeat [structural motif]
XM_017005130.2 → XP_016860619.1 plakophilin-4 isoform X11
XM_017005129.2 → XP_016860618.1 plakophilin-4 isoform X10

Conserved Domains (2) summary

cd00020
Location:374 → 496

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:382 → 407

ARM; armadillo repeat [structural motif]
XM_017005123.1 → XP_016860612.1 plakophilin-4 isoform X2

Conserved Domains (2) summary

cd00020
Location:521 → 643

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:529 → 554

ARM; armadillo repeat [structural motif]
XM_024453184.1 → XP_024308952.1 plakophilin-4 isoform X14

Conserved Domains (4) summary

smart00185
Location:523 → 558

ARM; Armadillo/beta-catenin-like repeats

pfam00514
Location:217 → 256

Arm; Armadillo/beta-catenin-like repeat

sd00043
Location:188 → 213

ARM; armadillo repeat [structural motif]

cl27106
Location:506 → 627

PLN03200; cellulose synthase-interactive protein; Provisional
XM_011512025.1 → XP_011510327.1 plakophilin-4 isoform X12

See identical proteins and their annotated locations for XP_011510327.1

Conserved Domains (2) summary

cd00020
Location:180 → 302

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:188 → 213

ARM; armadillo repeat [structural motif]
XM_017005131.1 → XP_016860620.1 plakophilin-4 isoform X13

Conserved Domains (2) summary

cd00020
Location:179 → 301

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:187 → 212

ARM; armadillo repeat [structural motif]