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PIGY phosphatidylinositol glycan anchor biosynthesis class Y [ Homo sapiens (human) ]

Gene ID: 84992, updated on 8-Jul-2021

Summary

Official Symbol
PIGYprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Yprovided by HGNC
Primary source
HGNC:HGNC:28213
See related
Ensembl:ENSG00000255072 MIM:610662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG-Y; HPMRS6
Summary
The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in adrenal (RPKM 45.6), fat (RPKM 42.6) and 25 other tissues See more
Orthologs
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Genomic context

See PIGY in Genome Data Viewer
Location:
4q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (88520998..88523776, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89442149..89444927, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723458 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 5 Neighboring gene nuclear receptor coactivator 4 pseudogene 2 Neighboring gene CD53 molecule pseudogene Neighboring gene PIGY divergent transcript Neighboring gene PIGY upstream open reading frame Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
GeneReviews: Not available
Hyperphosphatasia with mental retardation syndrome 6
MedGen: C4225201 OMIM: 616809 GeneReviews: Not available
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HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphatidylinositol glycan anchor biosynthesis, class Y (PIGY) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14156

General protein information

Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Names
phosphatidylinositol-glycan biosynthesis class Y protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046719.1 RefSeqGene

    Range
    5001..7824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042616.3NP_001036081.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

    See identical proteins and their annotated locations for NP_001036081.1

    Status: REVIEWED

    Source sequence(s)
    AB206972, BI548853, DB519150
    Consensus CDS
    CCDS54778.1
    UniProtKB/Swiss-Prot
    Q3MUY2
    Related
    ENSP00000432688.1, ENST00000527353.2
    Conserved Domains (1) summary
    pfam15159
    Location:4170
    PIG-Y; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    88520998..88523776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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