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PPFIA2 PTPRF interacting protein alpha 2 [ Homo sapiens (human) ]

Gene ID: 8499, updated on 13-Feb-2019

Summary

Official Symbol
PPFIA2provided by HGNC
Official Full Name
PTPRF interacting protein alpha 2provided by HGNC
Primary source
HGNC:HGNC:9246
See related
Ensembl:ENSG00000139220 MIM:603143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Biased expression in brain (RPKM 7.4), adrenal (RPKM 1.4) and 1 other tissue See more
Orthologs

Genomic context

See PPFIA2 in Genome Data Viewer
Location:
12q21.31
Exon count:
41
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (81257975..81759749, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (81652045..82153109, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984535 Neighboring gene acyl-CoA synthetase short chain family member 3 Neighboring gene microRNA 4699 Neighboring gene PPFIA2 antisense RNA 1 Neighboring gene uncharacterized LOC105369872 Neighboring gene vomeronasal 1 receptor 57 pseudogene Neighboring gene long intergenic non-protein coding RNA 2426

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study of multiplex schizophrenia pedigrees.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (PPFIA2) is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystemAcetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then...
  • Dopamine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Dopamine Neurotransmitter Release Cycle, organism-specific biosystemDopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused w...
  • Glutamate Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Glutamate Neurotransmitter Release Cycle, organism-specific biosystemCommunication at the synapse involves the release of glutamate from the presynaptic neuron and its binding to glutamate receptors on the postsynaptic cell to generate a series of events that lead to ...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
  • Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystemNoradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, con...
  • Serotonin Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
    Serotonin Neurotransmitter Release Cycle, organism-specific biosystemSerotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoa...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41378, MGC132572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of presynapse IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
presynapse organization IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
liprin-alpha-2
Names
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001220473.2NP_001207402.1  liprin-alpha-2 isoform b

    See identical proteins and their annotated locations for NP_001207402.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB210009, AW304872, BM661844, DA499362
    Consensus CDS
    CCDS59236.1
    UniProtKB/TrEMBL
    G3V200, Q4LE62
    Related
    ENSP00000449558.2, ENST00000550584.6
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10191084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:11041175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001220474.2NP_001207403.1  liprin-alpha-2 isoform c

    See identical proteins and their annotated locations for NP_001207403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB210009, AK126971, AW304872, BQ027545, CB051855, DA329958, DA499362, EL947964
    Consensus CDS
    CCDS55854.1
    UniProtKB/Swiss-Prot
    O75334
    UniProtKB/TrEMBL
    Q4LE62
    Related
    ENSP00000450298.1, ENST00000549325.5
    Conserved Domains (4) summary
    cd09562
    Location:880950
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10041069
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10891160
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:183515
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001220475.2NP_001207404.1  liprin-alpha-2 isoform d

    See identical proteins and their annotated locations for NP_001207404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AB210009, AW304872, BC104912, BM661844, CB051855, EL947964
    Consensus CDS
    CCDS55855.1
    UniProtKB/Swiss-Prot
    O75334
    UniProtKB/TrEMBL
    Q4LE62
    Related
    ENSP00000447868.1, ENST00000552948.5
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9981063
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10831154
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001220476.2NP_001207405.1  liprin-alpha-2 isoform e

    See identical proteins and their annotated locations for NP_001207405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform e, which is shorter than isoform a.
    Source sequence(s)
    AB210009, AW304872, BC143485, BM661844, CB051855, EL947964
    Consensus CDS
    CCDS55856.1
    UniProtKB/Swiss-Prot
    O75334
    UniProtKB/TrEMBL
    Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10131078
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10981169
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001220477.2NP_001207406.1  liprin-alpha-2 isoform f

    See identical proteins and their annotated locations for NP_001207406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform f, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK299853, AL713132, AW304872, BM661844, CB051855, DA329958, EL947964
    Consensus CDS
    CCDS55853.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000385093.4, ENST00000407050.8
    Conserved Domains (4) summary
    cd09562
    Location:821891
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:918983
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10031074
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:127459
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001220478.2NP_001207407.1  liprin-alpha-2 isoform g

    See identical proteins and their annotated locations for NP_001207407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform g, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK294505, AL713132, AW304872, BM661844, CB051855, DA687865, DC321269, EL947964
    Consensus CDS
    CCDS55852.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000327416.8, ENST00000333447.11
    Conserved Domains (4) summary
    cd09562
    Location:796866
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:914979
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:9991070
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:94434
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001220479.2NP_001207408.1  liprin-alpha-2 isoform h

    See identical proteins and their annotated locations for NP_001207408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the 5' UTR and coding region, compared to variant 1. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK296380, AW304872, BM661844, CB051855, DC322478, EL947964
    Consensus CDS
    CCDS55851.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000438337.2, ENST00000541570.6
    Conserved Domains (4) summary
    cd09562
    Location:462532
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:555620
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:640711
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:7264
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001220480.2NP_001207409.1  liprin-alpha-2 isoform i

    See identical proteins and their annotated locations for NP_001207409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the 5' UTR and coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform i), compared to isoform a.
    Source sequence(s)
    AK123372, AW304872, BM689808, CB051855, DC322478, EL947964
    Consensus CDS
    CCDS55850.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000445532.1, ENST00000541017.5
    Conserved Domains (3) summary
    cd09562
    Location:112182
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:205270
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:290361
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
  9. NM_001282536.1NP_001269465.1  liprin-alpha-2 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (j) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK302658, AW304872, BM661844, BU568524, CB051855, DB083201, EL947964
    Consensus CDS
    CCDS73503.1
    UniProtKB/TrEMBL
    B7Z7Y5, H0YHK3
    Related
    ENSP00000447273.2, ENST00000550359.6
    Conserved Domains (4) summary
    cd09562
    Location:742812
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:866931
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:9511022
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:36380
    SMC_N; RecF/RecN/SMC N terminal domain
  10. NM_003625.4NP_003616.2  liprin-alpha-2 isoform a

    See identical proteins and their annotated locations for NP_003616.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF034799, AW304872, BM661844, CB051855, DA329958, DA368637, DA533482, EL947964
    Consensus CDS
    CCDS55857.1
    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000450337.1, ENST00000549396.5
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10191084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:11041175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    81257975..81759749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449242.1XP_024305010.1  liprin-alpha-2 isoform X30

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9881053
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10731144
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_017020097.2XP_016875586.1  liprin-alpha-2 isoform X18

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9921057
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10771148
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_017020082.1XP_016875571.1  liprin-alpha-2 isoform X4

    UniProtKB/Swiss-Prot
    O75334
    Related
    ENSP00000449338.1, ENST00000548586.5
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10131078
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10981169
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_011538906.2XP_011537208.1  liprin-alpha-2 isoform X38

    See identical proteins and their annotated locations for XP_011537208.1

    Conserved Domains (4) summary
    cd09562
    Location:877947
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9641029
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10491120
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:183515
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_011538907.2XP_011537209.1  liprin-alpha-2 isoform X39

    See identical proteins and their annotated locations for XP_011537209.1

    Conserved Domains (5) summary
    cd09562
    Location:877947
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9951060
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10801151
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    smart00454
    Location:877943
    SAM; Sterile alpha motif
    cl02488
    Location:344518
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_017020084.1XP_016875573.1  liprin-alpha-2 isoform X6

  7. XM_017020102.2XP_016875591.1  liprin-alpha-2 isoform X23

    Conserved Domains (4) summary
    cd09562
    Location:870940
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9881053
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10731144
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:168508
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_017020110.2XP_016875599.1  liprin-alpha-2 isoform X31

  9. XM_017020088.1XP_016875577.1  liprin-alpha-2 isoform X10

  10. XM_024449243.1XP_024305011.1  liprin-alpha-2 isoform X32

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9821047
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10671138
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_017020101.1XP_016875590.1  liprin-alpha-2 isoform X22

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9881053
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10731144
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_017020107.2XP_016875596.1  liprin-alpha-2 isoform X28

  13. XM_024449240.1XP_024305008.1  liprin-alpha-2 isoform X14

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10091074
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10941165
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_017020090.2XP_016875579.1  liprin-alpha-2 isoform X11

  15. XM_017020086.1XP_016875575.1  liprin-alpha-2 isoform X8

    UniProtKB/TrEMBL
    G3V200, Q4LE62
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10191084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:11041175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  16. XM_017020108.2XP_016875597.1  liprin-alpha-2 isoform X29

  17. XM_017020098.1XP_016875587.1  liprin-alpha-2 isoform X19

    Conserved Domains (4) summary
    cd09562
    Location:898968
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9911056
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10761147
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  18. XM_017020079.1XP_016875568.1  liprin-alpha-2 isoform X1

    Conserved Domains (4) summary
    cd09562
    Location:898968
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10221087
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:11071178
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  19. XM_017020099.1XP_016875588.1  liprin-alpha-2 isoform X20

  20. XM_017020089.1XP_016875578.1  liprin-alpha-2 isoform X10

  21. XM_017020105.1XP_016875594.1  liprin-alpha-2 isoform X26

  22. XM_017020096.1XP_016875585.1  liprin-alpha-2 isoform X17

  23. XM_017020103.2XP_016875592.1  liprin-alpha-2 isoform X24

  24. XM_017020080.1XP_016875569.1  liprin-alpha-2 isoform X2

    UniProtKB/Swiss-Prot
    O75334
    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10191084
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:11041175
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  25. XM_017020100.2XP_016875589.1  liprin-alpha-2 isoform X21

  26. XM_017020091.2XP_016875580.1  liprin-alpha-2 isoform X12

  27. XM_017020087.2XP_016875576.1  liprin-alpha-2 isoform X9

  28. XM_017020118.1XP_016875607.1  liprin-alpha-2 isoform X33

  29. XM_017020120.2XP_016875609.1  liprin-alpha-2 isoform X34

  30. XM_024449245.1XP_024305013.1  liprin-alpha-2 isoform X36

    Conserved Domains (4) summary
    cd09562
    Location:490560
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:614679
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:699770
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:1289
    SMC_N; RecF/RecN/SMC N terminal domain
  31. XM_024449246.1XP_024305014.1  liprin-alpha-2 isoform X37

    Conserved Domains (4) summary
    cd09562
    Location:487557
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:605670
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:690761
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:1289
    SMC_N; RecF/RecN/SMC N terminal domain
  32. XM_017020094.2XP_016875583.1  liprin-alpha-2 isoform X15

  33. XM_024449241.1XP_024305009.1  liprin-alpha-2 isoform X27

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:9821047
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10671138
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  34. XM_024449239.1XP_024305007.1  liprin-alpha-2 isoform X7

    Conserved Domains (4) summary
    cd09562
    Location:895965
    SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
    cd09565
    Location:10091074
    SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
    cd09568
    Location:10941165
    SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
  35. XM_017020104.2XP_016875593.1  liprin-alpha-2 isoform X25

  36. XM_017020095.2XP_016875584.1  liprin-alpha-2 isoform X16

  37. XM_017020092.2XP_016875581.1  liprin-alpha-2 isoform X13

  38. XM_017020083.2XP_016875572.1  liprin-alpha-2 isoform X5

  39. XM_017020081.2XP_016875570.1  liprin-alpha-2 isoform X3

  40. XM_024449244.1XP_024305012.1  liprin-alpha-2 isoform X35

    Conserved Domains (1) summary
    cl25732
    Location:201533
    SMC_N; RecF/RecN/SMC N terminal domain
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