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TOX2 TOX high mobility group box family member 2 [ Homo sapiens (human) ]

Gene ID: 84969, updated on 11-Jun-2021

Summary

Official Symbol
TOX2provided by HGNC
Official Full Name
TOX high mobility group box family member 2provided by HGNC
Primary source
HGNC:HGNC:16095
See related
Ensembl:ENSG00000124191 MIM:611163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCX1; GCX-1; C20orf100; dJ495O3.1; dJ1108D11.2
Expression
Broad expression in testis (RPKM 5.3), lymph node (RPKM 4.6) and 21 other tissues See more
Orthologs
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Genomic context

See TOX2 in Genome Data Viewer
Location:
20q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (43914852..44069616)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42543492..42698256)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927200 Neighboring gene uncharacterized LOC105372625 Neighboring gene long intergenic non-protein coding RNA 1728 Neighboring gene Sharpr-MPRA regulatory region 6747 Neighboring gene RNA, 7SL, cytoplasmic 443, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7745 Neighboring gene JPH2 intron CAGE-defined T cell enhancer Neighboring gene junctophilin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of conduct disorder symptomatology.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15880

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TOX high mobility group box family member 2
Names
granulosa cell HMG box 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098796.2NP_001092266.1  TOX high mobility group box family member 2 isoform c

    See identical proteins and their annotated locations for NP_001092266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon at its 5' end, which produces a unique 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AL035089, BC007636, BM545579, DA174963
    Consensus CDS
    CCDS13324.1
    UniProtKB/Swiss-Prot
    Q96NM4
    Related
    ENSP00000390278.1, ENST00000423191.6
    Conserved Domains (1) summary
    cd00084
    Location:204269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. NM_001098797.2NP_001092267.1  TOX high mobility group box family member 2 isoform a

    See identical proteins and their annotated locations for NP_001092267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC007636, CB989964
    Consensus CDS
    CCDS46603.1
    UniProtKB/Swiss-Prot
    Q96NM4
    Related
    ENSP00000344724.3, ENST00000341197.9
    Conserved Domains (1) summary
    cd00084
    Location:246311
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  3. NM_001098798.2NP_001092268.1  TOX high mobility group box family member 2 isoform b

    See identical proteins and their annotated locations for NP_001092268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon at its 5' end and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform b) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK055135, BC007636, DA210275
    Consensus CDS
    CCDS42875.1
    UniProtKB/Swiss-Prot
    Q96NM4
    Related
    ENSP00000350849.5, ENST00000358131.5
    Conserved Domains (1) summary
    cd00084
    Location:255302
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  4. NM_032883.3NP_116272.1  TOX high mobility group box family member 2 isoform c

    See identical proteins and their annotated locations for NP_116272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform c) is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AL035089, BC007636, BM545579
    Consensus CDS
    CCDS13324.1
    UniProtKB/Swiss-Prot
    Q96NM4
    Related
    ENSP00000362090.1, ENST00000372999.5
    Conserved Domains (1) summary
    cd00084
    Location:204269
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    43914852..44069616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723884.1XP_006723947.1  TOX high mobility group box family member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96NM4
    Conserved Domains (1) summary
    cd00084
    Location:255320
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
  2. XM_017028109.1XP_016883598.1  TOX high mobility group box family member 2 isoform X2

RNA

  1. XR_001754425.1 RNA Sequence

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