U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LSM10 LSM10, U7 small nuclear RNA associated [ Homo sapiens (human) ]

Gene ID: 84967, updated on 1-Mar-2024

Summary

Official Symbol
LSM10provided by HGNC
Official Full Name
LSM10, U7 small nuclear RNA associatedprovided by HGNC
Primary source
HGNC:HGNC:17562
See related
Ensembl:ENSG00000181817 MIM:617909; AllianceGenome:HGNC:17562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST074; MSTP074
Summary
Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in Cajal body. Part of U7 snRNP. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 20.1), spleen (RPKM 17.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LSM10 in Genome Data Viewer
Location:
1p34.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36393436..36397908, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (36256320..36260783, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36859037..36863509, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 751 Neighboring gene serine/threonine kinase 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36823274-36823774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36834695-36835363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36835364-36836031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36837681-36838244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36838245-36838808 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36839045-36840244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36844393-36844892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 668 Neighboring gene uncharacterized LOC124904012 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:36851839-36853038 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36862654-36863366 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36863367-36864078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36865796-36866392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36866393-36866988 Neighboring gene uncharacterized LOC124904013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 754 Neighboring gene RNA, U4 small nuclear 27, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 63C Neighboring gene organic solute carrier partner 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: STK40

Clone Names

  • MGC15749

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables U7 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables U7 snRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone pre-mRNA DCP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone pre-mRNA DCP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
part_of U7 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytoplasmic U snRNP body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
U7 snRNA-associated Sm-like protein LSm10
Names
U7 snRNP-specific Sm-like protein LSM10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032881.3NP_116270.1  U7 snRNA-associated Sm-like protein LSm10

    See identical proteins and their annotated locations for NP_116270.1

    Status: VALIDATED

    Source sequence(s)
    AC119675, AI150247, BC007623
    Consensus CDS
    CCDS408.1
    UniProtKB/Swiss-Prot
    Q969L4
    UniProtKB/TrEMBL
    Q7Z2T2
    Related
    ENSP00000319341.2, ENST00000315732.3
    Conserved Domains (1) summary
    cd01733
    Location:885
    LSm10; Like-Sm protein 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    36393436..36397908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    36256320..36260783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)