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IGSF21 immunoglobin superfamily member 21 [ Homo sapiens (human) ]

Gene ID: 84966, updated on 1-Jun-2020

Summary

Official Symbol
IGSF21provided by HGNC
Official Full Name
immunoglobin superfamily member 21provided by HGNC
Primary source
HGNC:HGNC:28246
See related
Ensembl:ENSG00000117154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 11.7), spleen (RPKM 6.4) and 6 other tissues See more
Orthologs

Genomic context

See IGSF21 in Genome Data Viewer
Location:
1p36.13
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (18107746..18378483)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (18434240..18704977)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376812 Neighboring gene long intergenic non-protein coding RNA 1654 Neighboring gene IGSF21 antisense RNA 1 Neighboring gene kelch domain containing 7A Neighboring gene dynein light chain LC8-type 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
NHGRI GWA Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41177, MGC15730

Gene Ontology Provided by GOA

Process Evidence Code Pubs
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
immunoglobulin superfamily member 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027535.2 RefSeqGene

    Range
    5053..275738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032880.5NP_116269.3  immunoglobulin superfamily member 21 precursor

    See identical proteins and their annotated locations for NP_116269.3

    Status: REVIEWED

    Source sequence(s)
    AK075316, AL356101, BC007618
    Consensus CDS
    CCDS184.1
    UniProtKB/Swiss-Prot
    Q96ID5
    Related
    ENSP00000251296.1, ENST00000251296.4
    Conserved Domains (2) summary
    smart00410
    Location:353430
    IG_like; Immunoglobulin like
    cl11960
    Location:369432
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    18107746..18378483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542319.3XP_011540621.1  immunoglobulin superfamily member 21 isoform X4

    Conserved Domains (2) summary
    smart00410
    Location:156233
    IG_like; Immunoglobulin like
    cl11960
    Location:172235
    Ig; Immunoglobulin domain
  2. XM_024450444.1XP_024306212.1  immunoglobulin superfamily member 21 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:319379
    Ig; Immunoglobulin domain
  3. XM_017002604.2XP_016858093.1  immunoglobulin superfamily member 21 isoform X1

    Conserved Domains (2) summary
    smart00410
    Location:347424
    IG_like; Immunoglobulin like
    cl11960
    Location:363426
    Ig; Immunoglobulin domain
  4. XM_017002605.1XP_016858094.1  immunoglobulin superfamily member 21 isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:276353
    IG_like; Immunoglobulin like
    cl11960
    Location:292355
    Ig; Immunoglobulin domain
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