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AJUBA ajuba LIM protein [ Homo sapiens (human) ]

Gene ID: 84962, updated on 7-Jun-2020

Summary

Official Symbol
AJUBAprovided by HGNC
Official Full Name
ajuba LIM proteinprovided by HGNC
Primary source
HGNC:HGNC:20250
See related
Ensembl:ENSG00000129474 MIM:609066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JUB
Expression
Broad expression in skin (RPKM 17.2), liver (RPKM 8.4) and 15 other tissues See more
Orthologs

Genomic context

See AJUBA in Genome Data Viewer
Location:
14q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22971177..22982551, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23440386..23451851, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926933 Neighboring gene tRNA-Arg (anticodon ACG) 1-3 Neighboring gene HAUS augmin like complex subunit 4 Neighboring gene microRNA 4707 Neighboring gene Sharpr-MPRA regulatory region 809 Neighboring gene uncharacterized LOC107984660 Neighboring gene chromosome 14 open reading frame 93 Neighboring gene Sharpr-MPRA regulatory region 11879 Neighboring gene proteasome 20S subunit beta 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15563

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycerophospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene silencing by miRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
P-body IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
LIM domain-containing protein ajuba
Names
jub, ajuba homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289097.2NP_001276026.1  LIM domain-containing protein ajuba isoform 3

    See identical proteins and their annotated locations for NP_001276026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA909473, AL132780, BC034968, BX109281
    UniProtKB/Swiss-Prot
    Q96IF1
  2. NM_032876.6NP_116265.1  LIM domain-containing protein ajuba isoform 1

    See identical proteins and their annotated locations for NP_116265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL132780
    Consensus CDS
    CCDS9581.1
    UniProtKB/Swiss-Prot
    Q96IF1
    Related
    ENSP00000262713.2, ENST00000262713.7
    Conserved Domains (3) summary
    cd09352
    Location:338391
    LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
    cd09355
    Location:403455
    LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
    cd09438
    Location:463524
    LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
  3. NM_198086.3NP_932352.1  LIM domain-containing protein ajuba isoform 2

    See identical proteins and their annotated locations for NP_932352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL132780
    Consensus CDS
    CCDS9582.1
    UniProtKB/Swiss-Prot
    Q96IF1
    Related
    ENSP00000380543.3, ENST00000397388.7
    Conserved Domains (1) summary
    cl02475
    Location:46107
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22971177..22982551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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