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UBASH3B ubiquitin associated and SH3 domain containing B [ Homo sapiens (human) ]

Gene ID: 84959, updated on 7-Dec-2018

Summary

Official Symbol
UBASH3Bprovided by HGNC
Official Full Name
ubiquitin associated and SH3 domain containing Bprovided by HGNC
Primary source
HGNC:HGNC:29884
See related
Ensembl:ENSG00000154127 MIM:609201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p70; STS1; STS-1; TULA2; TULA-2
Summary
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues See more
Orthologs

Genomic context

See UBASH3B in Genome Data Viewer
Location:
11q24.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (122655690..122814479)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122526398..122685187)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 592, pseudogene Neighboring gene glutamate-ammonia ligase pseudogene 3 Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene junctional cadherin complex regulator Neighboring gene RNA, U4 small nuclear 23, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1959, MGC15437

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
collagen-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin-associated and SH3 domain-containing protein B
Names
Cbl-interacting protein Sts-1
SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
T-cell ubiquitin ligand 2
cbl-interacting protein p70
nm23-phosphorylated unknown substrate
suppressor of T-cell receptor signaling 1
tyrosine-protein phosphatase STS1/TULA2
NP_116262.2
XP_005271769.1
XP_011541343.1
XP_011541344.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363365.1NP_001350294.1  ubiquitin-associated and SH3 domain-containing protein B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP002762
    Conserved Domains (2) summary
    cd07067
    Location:351563
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:221282
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
  2. NM_032873.5NP_116262.2  ubiquitin-associated and SH3 domain-containing protein B isoform 1

    See identical proteins and their annotated locations for NP_116262.2

    Status: VALIDATED

    Source sequence(s)
    AK075203, AP002762, BC007541, CR741636
    Consensus CDS
    CCDS31694.1
    UniProtKB/Swiss-Prot
    Q8TF42
    Related
    ENSP00000284273.5, ENST00000284273.5
    Conserved Domains (3) summary
    cd07067
    Location:386598
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:256317
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cd14301
    Location:3976
    UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    122655690..122814479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543042.2XP_011541344.1  ubiquitin-associated and SH3 domain-containing protein B isoform X3

    Conserved Domains (2) summary
    cd07067
    Location:351563
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:221282
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
  2. XM_005271712.3XP_005271769.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

    Conserved Domains (3) summary
    cd07067
    Location:414626
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:284345
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cl21463
    Location:83104
    UBA_like_SF; UBA domain-like superfamily
  3. XM_011543041.2XP_011541343.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

    Conserved Domains (2) summary
    cd07067
    Location:367579
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:237298
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
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