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SYTL1 synaptotagmin like 1 [ Homo sapiens (human) ]

Gene ID: 84958, updated on 17-Jun-2019

Summary

Official Symbol
SYTL1provided by HGNC
Official Full Name
synaptotagmin like 1provided by HGNC
Primary source
HGNC:HGNC:15584
See related
Ensembl:ENSG00000142765 MIM:608042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFC1; SLP1
Expression
Broad expression in prostate (RPKM 24.6), skin (RPKM 21.7) and 16 other tissues See more
Orthologs

Genomic context

See SYTL1 in Genome Data Viewer
Location:
1p36.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (27342022..27353932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27668483..27680423)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene transmembrane protein 222 Neighboring gene actin gamma 1 pseudogene 20 Neighboring gene RNA, U6 small nuclear 48, pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene ficolin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystemExample of the Rab27 cluster. The Rab27 cluster is comprised of the two RAB27 isoforms (RAB27A and RAB27B), the GEF MADD, the GAP TBC1D10A and 12 effector proteins
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14996

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
neurexin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
melanosome ISS
Inferred from Sequence or Structural Similarity
more info
 
microvillus membrane TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-like protein 1
Names
NADPH oxidase-related, C2 domain-containing protein
exophilin-7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193308.2NP_001180237.1  synaptotagmin-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001180237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC035725, DA948740
    Consensus CDS
    CCDS53286.1
    UniProtKB/Swiss-Prot
    Q8IYJ3
    Related
    ENSP00000481032.1, ENST00000616558.5
    Conserved Domains (3) summary
    cd04020
    Location:399555
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:267386
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:3599
    PHD_SF; PHD finger superfamily
  2. NM_032872.3NP_116261.1  synaptotagmin-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_116261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK027902, CB851688
    Consensus CDS
    CCDS298.1
    UniProtKB/Swiss-Prot
    Q8IYJ3
    Related
    ENSP00000316464.5, ENST00000318074.9
    Conserved Domains (3) summary
    cd04020
    Location:387543
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:255374
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:3599
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    27342022..27353932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450438.1XP_024306206.1  synaptotagmin-like protein 1 isoform X3

    Conserved Domains (4) summary
    cd04020
    Location:450606
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:318437
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:3599
    PHD_SF; PHD finger superfamily
    cl28271
    Location:103279
    dnaA; chromosomal replication initiation protein; Provisional
  2. XM_024450441.1XP_024306209.1  synaptotagmin-like protein 1 isoform X4

    Conserved Domains (4) summary
    cd04020
    Location:438594
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:306425
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:3599
    PHD_SF; PHD finger superfamily
    cl28271
    Location:103267
    dnaA; chromosomal replication initiation protein; Provisional
  3. XM_006710991.2XP_006711054.1  synaptotagmin-like protein 1 isoform X7

    Conserved Domains (2) summary
    cd04020
    Location:192348
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cl14603
    Location:84179
    C2; C2 domain
  4. XM_024450435.1XP_024306203.1  synaptotagmin-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:482638
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:350469
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:67131
    PHD_SF; PHD finger superfamily
    cl28271
    Location:135311
    dnaA; chromosomal replication initiation protein; Provisional
  5. XM_005246022.3XP_005246079.1  synaptotagmin-like protein 1 isoform X5

    Conserved Domains (3) summary
    cd04020
    Location:431587
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:299418
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:67131
    PHD_SF; PHD finger superfamily
  6. XM_024450436.1XP_024306204.1  synaptotagmin-like protein 1 isoform X2

    Conserved Domains (4) summary
    cd04020
    Location:470626
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:338457
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:67131
    PHD_SF; PHD finger superfamily
    cl28271
    Location:135299
    dnaA; chromosomal replication initiation protein; Provisional
  7. XM_006710990.1XP_006711053.1  synaptotagmin-like protein 1 isoform X6

    Conserved Domains (3) summary
    cd04020
    Location:419575
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08393
    Location:287406
    C2A_SLP-1_2; C2 domain first repeat present in Synaptotagmin-like proteins 1 and 2
    cl22851
    Location:67131
    PHD_SF; PHD finger superfamily

RNA

  1. XR_002957843.1 RNA Sequence

    Related
    ENST00000483926.5
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