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RELT RELT TNF receptor [ Homo sapiens (human) ]

Gene ID: 84957, updated on 22-Sep-2022

Summary

Official Symbol
RELTprovided by HGNC
Official Full Name
RELT TNF receptorprovided by HGNC
Primary source
HGNC:HGNC:13764
See related
Ensembl:ENSG00000054967 MIM:611211; AllianceGenome:HGNC:13764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AI3C; TRLT; TNFRSF19L
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 25.4), spleen (RPKM 6.1) and 8 other tissues See more
Orthologs
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Genomic context

See RELT in Genome Data Viewer
Location:
11q13.4
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73376399..73397474)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73305536..73326611)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73087444..73108519)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene uncharacterized LOC124902710 Neighboring gene Sharpr-MPRA regulatory region 4120 Neighboring gene Sharpr-MPRA regulatory region 2034 Neighboring gene family with sequence similarity 168 member A Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of RELT PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amelogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in amelogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 19L
Names
RELT tumor necrosis factor receptor
receptor expressed in lymphoid tissues

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032871.4NP_116260.2  tumor necrosis factor receptor superfamily member 19L precursor

    See identical proteins and their annotated locations for NP_116260.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AP000562, AP000763
    Consensus CDS
    CCDS8222.1
    UniProtKB/Swiss-Prot
    Q969Z4, Q9BUX7
    UniProtKB/TrEMBL
    A0A024R5N3
    Related
    ENSP00000377207.2, ENST00000393580.2
    Conserved Domains (2) summary
    cd13419
    Location:27112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:163198
    RELT; tumor necrosis factor receptor superfamily member 19
  2. NM_152222.2NP_689408.1  tumor necrosis factor receptor superfamily member 19L precursor

    See identical proteins and their annotated locations for NP_689408.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AP000562, AP000763
    Consensus CDS
    CCDS8222.1
    UniProtKB/Swiss-Prot
    Q969Z4, Q9BUX7
    UniProtKB/TrEMBL
    A0A024R5N3
    Related
    ENSP00000064780.2, ENST00000064780.7
    Conserved Domains (2) summary
    cd13419
    Location:27112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:163198
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    73376399..73397474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427758.1XP_047283714.1  tumor necrosis factor receptor superfamily member 19L isoform X2

  2. XM_047427757.1XP_047283713.1  tumor necrosis factor receptor superfamily member 19L isoform X1

  3. XM_047427759.1XP_047283715.1  tumor necrosis factor receptor superfamily member 19L isoform X3

  4. XM_047427760.1XP_047283716.1  tumor necrosis factor receptor superfamily member 19L isoform X4

  5. XM_047427761.1XP_047283717.1  tumor necrosis factor receptor superfamily member 19L isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    73305536..73326611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)