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MPND MPN domain containing [ Homo sapiens (human) ]

Gene ID: 84954, updated on 5-Aug-2022

Summary

Official Symbol
MPNDprovided by HGNC
Official Full Name
MPN domain containingprovided by HGNC
Primary source
HGNC:HGNC:25934
See related
Ensembl:ENSG00000008382 AllianceGenome:HGNC:25934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable histone binding activity; peptidase activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 12.4), duodenum (RPKM 11.4) and 25 other tissues See more
Orthologs
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Genomic context

See MPND in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4343562..4360078)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4327019..4343527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4343559..4360075)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene signal transducing adaptor family member 2 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 6 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene Sharpr-MPRA regulatory regions 262 and 14493 Neighboring gene Sharpr-MPRA regulatory regions 465 and 6457

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ14981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MPN domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159846.3NP_001153318.1  MPN domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001153318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate exons in the 3' coding region, compared to variant 3. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 3.
    Source sequence(s)
    AC007292
    Consensus CDS
    CCDS54200.1
    UniProtKB/Swiss-Prot
    Q8N594
    Related
    ENSP00000353015.3, ENST00000359935.8
    Conserved Domains (2) summary
    pfam18755
    Location:72167
    RAMA; Restriction Enzyme Adenine Methylase Associated
    cl13996
    Location:266400
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains
  2. NM_001300862.2NP_001287791.1  MPN domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_001287791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC007292
    Consensus CDS
    CCDS74261.1
    UniProtKB/TrEMBL
    W4VSR2
    Related
    ENSP00000471735.1, ENST00000599840.6
    Conserved Domains (1) summary
    cd08067
    Location:266450
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
  3. NM_032868.6NP_116257.2  MPN domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_116257.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. It encodes isoform 1, which lacks an internal segment and is shorter, compared to isoform 3.
    Source sequence(s)
    AC007292
    Consensus CDS
    CCDS42470.1
    UniProtKB/Swiss-Prot
    Q8N594, Q9Y2P2
    Related
    ENSP00000262966.7, ENST00000262966.12
    Conserved Domains (1) summary
    cd08067
    Location:266443
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4343562..4360078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722926.3XP_006722989.1  MPN domain-containing protein isoform X1

    Related
    ENSP00000471189.1, ENST00000597036.5
    Conserved Domains (1) summary
    cd08067
    Location:266421
    MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4327019..4343527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)