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TNS4 tensin 4 [ Homo sapiens (human) ]

Gene ID: 84951, updated on 17-May-2020

Summary

Official Symbol
TNS4provided by HGNC
Official Full Name
tensin 4provided by HGNC
Primary source
HGNC:HGNC:24352
See related
Ensembl:ENSG00000131746 MIM:608385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTEN; PP14434
Expression
Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues See more
Orthologs

Genomic context

See TNS4 in Genome Data Viewer
Location:
17q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40475828..40501681, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38632080..38657933, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene insulin like growth factor binding protein 4 Neighboring gene uncharacterized LOC107985064 Neighboring gene uncharacterized LOC105371773 Neighboring gene uncharacterized LOC101059954

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tensin-4
Names
C terminal tensin like
C-terminal tensin-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032865.6NP_116254.4  tensin-4 precursor

    See identical proteins and their annotated locations for NP_116254.4

    Status: VALIDATED

    Source sequence(s)
    AC018629, AF417488, AW378527, AW937802, BC018706, BM710196
    Consensus CDS
    CCDS11368.1
    UniProtKB/Swiss-Prot
    Q8IZW8
    UniProtKB/TrEMBL
    Q6PJP3
    Related
    ENSP00000254051.6, ENST00000254051.11
    Conserved Domains (2) summary
    cd01213
    Location:580710
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl15255
    Location:445558
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40475828..40501681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257744.1XP_005257801.1  tensin-4 isoform X1

    Conserved Domains (2) summary
    cd01213
    Location:579709
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cl15255
    Location:444557
    SH2; Src homology 2 (SH2) domain
  2. XM_017025236.1XP_016880725.1  tensin-4 isoform X2

  3. XM_017025237.1XP_016880726.1  tensin-4 isoform X3

RNA

  1. XR_001752669.1 RNA Sequence

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