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CORO6 coronin 6 [ Homo sapiens (human) ]

Gene ID: 84940, updated on 3-Apr-2024

Summary

Official Symbol
CORO6provided by HGNC
Official Full Name
coronin 6provided by HGNC
Primary source
HGNC:HGNC:21356
See related
Ensembl:ENSG00000167549 AllianceGenome:HGNC:21356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ClipinE
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 15.3), placenta (RPKM 14.7) and 12 other tissues See more
Orthologs
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Genomic context

Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29614762..29622912, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30557663..30565813, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27941780..27949930, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911138-27911952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911953-27912765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27914948-27915847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27916747-27917646 Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11982 Neighboring gene ankyrin repeat domain 13B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27940429-27941292 Neighboring gene GIT ArfGAP 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27942158-27943021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8384 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8385 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:27950531-27951730 Neighboring gene NANOG hESC enhancer GRCh37_chr17:27960948-27961512 Neighboring gene uncharacterized LOC107984990 Neighboring gene Sharpr-MPRA regulatory region 11433 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene slingshot protein phosphatase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
coronin-6
Names
clipin-E
coronin, actin binding protein 6
coronin-like protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054920.1 RefSeqGene

    Range
    4997..13147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351301.3NP_001338230.1  coronin-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    B3KRY9
    Conserved Domains (1) summary
    cl29593
    Location:21231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001351302.3NP_001338231.1  coronin-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    B3KRY9
    Related
    ENST00000469090.5
    Conserved Domains (1) summary
    cl29593
    Location:21231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001388431.1NP_001375360.1  coronin-6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC104564
    Consensus CDS
    CCDS11252.2
    UniProtKB/Swiss-Prot
    B3KU26, Q6QEF8, Q71MF3, Q8WYH7, Q96K02
    Related
    ENSP00000344562.5, ENST00000345068.9
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9454
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001388433.1NP_001375362.1  coronin-6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3KSS5
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_001388434.1NP_001375363.1  coronin-6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3KSS5
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9465
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. NM_001388435.1NP_001375364.1  coronin-6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3QLV6
    Conserved Domains (2) summary
    sd00039
    Location:3188
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9413
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. NM_001388436.1NP_001375365.1  coronin-6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3QLV6
    Related
    ENSP00000463723.1, ENST00000580212.6
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9425
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. NM_001388437.1NP_001375366.1  coronin-6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3QLV6
    Conserved Domains (2) summary
    sd00039
    Location:3188
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9424
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. NM_001388438.1NP_001375367.1  coronin-6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC104564
    UniProtKB/TrEMBL
    J3QLV6
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9379
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. NM_032854.4NP_116243.2  coronin-6 isoform 1

    See identical proteins and their annotated locations for NP_116243.2

    Status: VALIDATED

    Source sequence(s)
    AC104564
    Consensus CDS
    CCDS11252.2
    UniProtKB/Swiss-Prot
    B3KU26, Q6QEF8, Q71MF3, Q8WYH7, Q96K02
    Related
    ENSP00000373419.3, ENST00000388767.8
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9454
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_170977.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104564
  2. NR_170978.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104564

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    29614762..29622912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525387.4XP_011523689.1  coronin-6 isoform X2

    Conserved Domains (5) summary
    PTZ00421
    Location:80484
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:374416
    WD40_4; Type of WD40 repeat
    sd00039
    Location:102159
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:106326
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011525386.4XP_011523688.1  coronin-6 isoform X1

    UniProtKB/TrEMBL
    J3QLV6
    Conserved Domains (5) summary
    PTZ00421
    Location:80490
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:380422
    WD40_4; Type of WD40 repeat
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011525390.4XP_011523692.1  coronin-6 isoform X6

    See identical proteins and their annotated locations for XP_011523692.1

    UniProtKB/TrEMBL
    B3KRY9, B3KSZ9
    Conserved Domains (1) summary
    cl25676
    Location:21220
    WD40_4; Type of WD40 repeat
  4. XM_011525391.4XP_011523693.1  coronin-6 isoform X6

    See identical proteins and their annotated locations for XP_011523693.1

    UniProtKB/TrEMBL
    B3KRY9, B3KSZ9
    Conserved Domains (1) summary
    cl25676
    Location:21220
    WD40_4; Type of WD40 repeat
  5. XM_011525388.3XP_011523690.1  coronin-6 isoform X3

    Conserved Domains (3) summary
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149367
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_047436948.1XP_047292904.1  coronin-6 isoform X4

  7. XM_011525389.4XP_011523691.1  coronin-6 isoform X5

    See identical proteins and their annotated locations for XP_011523691.1

    Conserved Domains (3) summary
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    30557663..30565813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317584.1XP_054173559.1  coronin-6 isoform X2

  2. XM_054317583.1XP_054173558.1  coronin-6 isoform X1

  3. XM_054317588.1XP_054173563.1  coronin-6 isoform X6

    UniProtKB/TrEMBL
    B3KSZ9
  4. XM_054317589.1XP_054173564.1  coronin-6 isoform X6

    UniProtKB/TrEMBL
    B3KSZ9
  5. XM_054317585.1XP_054173560.1  coronin-6 isoform X3

  6. XM_054317586.1XP_054173561.1  coronin-6 isoform X4

  7. XM_054317587.1XP_054173562.1  coronin-6 isoform X5