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CORO6 coronin 6 [ Homo sapiens (human) ]

Gene ID: 84940, updated on 12-Oct-2019

Summary

Official Symbol
CORO6provided by HGNC
Official Full Name
coronin 6provided by HGNC
Primary source
HGNC:HGNC:21356
See related
Ensembl:ENSG00000167549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in heart (RPKM 15.3), placenta (RPKM 14.7) and 12 other tissues See more
Orthologs

Genomic context

See CORO6 in Genome Data Viewer
Location:
17q11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (29614236..29622912, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27941774..27949926, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene ankyrin repeat domain 13B Neighboring gene GIT ArfGAP 1 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene uncharacterized LOC107984990 Neighboring gene Sharpr-MPRA regulatory region 11433 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene slingshot protein phosphatase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
coronin-6
Names
clipin-E
coronin, actin binding protein 6
coronin-like protein E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054920.1 RefSeqGene

    Range
    6486..13153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351301.1NP_001338230.1  coronin-6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK092430, BC064514
    Conserved Domains (1) summary
    cl25676
    Location:21231
    WD40_4; Type of WD40 repeat
  2. NM_001351302.1NP_001338231.1  coronin-6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AF447884, AK092430
    Conserved Domains (1) summary
    cl25676
    Location:21231
    WD40_4; Type of WD40 repeat
  3. NM_032854.3NP_116243.2  coronin-6 isoform 1

    See identical proteins and their annotated locations for NP_116243.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104564, AK092430, AK096431, BI758263
    Consensus CDS
    CCDS11252.2
    UniProtKB/Swiss-Prot
    Q6QEF8
    UniProtKB/TrEMBL
    B3KRY9
    Related
    ENSP00000373419.3, ENST00000388767.7
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:9454
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    29614236..29622912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025235.2XP_016880724.1  coronin-6 isoform X8

  2. XM_005258047.4XP_005258104.1  coronin-6 isoform X6

    See identical proteins and their annotated locations for XP_005258104.1

    UniProtKB/Swiss-Prot
    Q6QEF8
    Conserved Domains (2) summary
    sd00039
    Location:3779
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:9454
    WD40_4; Type of WD40 repeat
  3. XM_011525387.3XP_011523689.1  coronin-6 isoform X4

    Conserved Domains (5) summary
    PTZ00421
    Location:80484
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:374416
    WD40_4; Type of WD40 repeat
    sd00039
    Location:102159
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:106326
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_011525386.3XP_011523688.1  coronin-6 isoform X3

    Conserved Domains (5) summary
    PTZ00421
    Location:80490
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:380422
    WD40_4; Type of WD40 repeat
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_005258048.5XP_005258105.2  coronin-6 isoform X1

    Conserved Domains (5) summary
    PTZ00421
    Location:80525
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:415457
    WD40_4; Type of WD40 repeat
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149367
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_011525391.3XP_011523693.1  coronin-6 isoform X10

    See identical proteins and their annotated locations for XP_011523693.1

    UniProtKB/TrEMBL
    B3KSZ9
    Conserved Domains (1) summary
    pfam16300
    Location:110152
    WD40_4; Type of WD40 repeat
  7. XM_011525390.3XP_011523692.1  coronin-6 isoform X10

    See identical proteins and their annotated locations for XP_011523692.1

    UniProtKB/TrEMBL
    B3KSZ9
    Conserved Domains (1) summary
    pfam16300
    Location:110152
    WD40_4; Type of WD40 repeat
  8. XM_024451010.1XP_024306778.1  coronin-6 isoform X10

  9. XM_024451009.1XP_024306777.1  coronin-6 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:102159
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:80495
    WD40_4; Type of WD40 repeat
  10. XM_011525385.3XP_011523687.1  coronin-6 isoform X2

    Conserved Domains (5) summary
    PTZ00421
    Location:80536
    PTZ00421; coronin; Provisional
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:415457
    WD40_4; Type of WD40 repeat
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149367
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_005258056.5XP_005258113.1  coronin-6 isoform X11

    See identical proteins and their annotated locations for XP_005258113.1

    UniProtKB/Swiss-Prot
    Q6QEF8
    Conserved Domains (1) summary
    cl25676
    Location:21231
    WD40_4; Type of WD40 repeat
  12. XM_011525388.2XP_011523690.1  coronin-6 isoform X7

    Conserved Domains (3) summary
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149367
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_011525389.3XP_011523691.1  coronin-6 isoform X9

    See identical proteins and their annotated locations for XP_011523691.1

    Conserved Domains (3) summary
    pfam08953
    Location:78135
    DUF1899; Domain of unknown function (DUF1899)
    sd00039
    Location:108150
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_934579.3 RNA Sequence

  2. XR_934578.3 RNA Sequence

  3. XR_001752668.1 RNA Sequence

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