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RAB2B RAB2B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 84932, updated on 10-Oct-2019

Summary

Official Symbol
RAB2Bprovided by HGNC
Official Full Name
RAB2B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:20246
See related
Ensembl:ENSG00000129472 MIM:607466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]
Expression
Ubiquitous expression in bone marrow (RPKM 6.9), testis (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See RAB2B in Genome Data Viewer
Location:
14q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (21459020..21476959, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21927179..21945132, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 650, pseudogene Neighboring gene TOX high mobility group box family member 4 Neighboring gene methyltransferase like 3 Neighboring gene spalt like transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
    RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras-related protein Rab-2B
Names
GTP-binding protein RAB2B
RAS family, member RAB2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163380.2NP_001156852.1  ras-related protein Rab-2B isoform 2

    See identical proteins and their annotated locations for NP_001156852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK300599, AL161747, BC066366, BG535306
    UniProtKB/Swiss-Prot
    Q8WUD1
    UniProtKB/TrEMBL
    B4DUD4
    Conserved Domains (1) summary
    cl21455
    Location:1124
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_032846.4NP_116235.2  ras-related protein Rab-2B isoform 1

    See identical proteins and their annotated locations for NP_116235.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL161747, BC020839, BC066366
    Consensus CDS
    CCDS9570.1
    UniProtKB/Swiss-Prot
    Q8WUD1
    Related
    ENSP00000380869.1, ENST00000397762.6
    Conserved Domains (1) summary
    cl27030
    Location:1216
    Ras; Ras family

RNA

  1. NR_028074.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region that results in a frameshift, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL161747, BC066366, CD634472

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    21459020..21476959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021710.1XP_016877199.1  ras-related protein Rab-2B isoform X1

    Conserved Domains (1) summary
    cl21455
    Location:18125
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017021712.1XP_016877201.1  ras-related protein Rab-2B isoform X2

    Conserved Domains (1) summary
    cl21455
    Location:9101
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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