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TMEM209 transmembrane protein 209 [ Homo sapiens (human) ]

Gene ID: 84928, updated on 24-Nov-2020

Summary

Official Symbol
TMEM209provided by HGNC
Official Full Name
transmembrane protein 209provided by HGNC
Primary source
HGNC:HGNC:21898
See related
Ensembl:ENSG00000146842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET31
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 7.9) and 25 other tissues See more
Orthologs

Genomic context

See TMEM209 in Genome Data Viewer
Location:
7q32.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (130164713..130205406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (129804555..129845338, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene kelch domain containing 10 Neighboring gene uncharacterized LOC100128325 Neighboring gene serine rich single-pass membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 5425 Neighboring gene carboxypeptidase A2 Neighboring gene uncharacterized LOC105375503 Neighboring gene carboxypeptidase A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 209 (TMEM209) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14803

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 209
Names
testicular tissue protein Li 202

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301163.2NP_001288092.1  transmembrane protein 209 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK027709, BC045618, BC057784, DB021198, HY352956
    Consensus CDS
    CCDS75661.1
    UniProtKB/Swiss-Prot
    Q96SK2
    Related
    ENSP00000417258.1, ENST00000473456.5
    Conserved Domains (1) summary
    pfam09786
    Location:11518
    CytochromB561_N; Cytochrome B561, N terminal
  2. NM_001363478.2NP_001350407.1  transmembrane protein 209 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087071, BC045618, BU430476, DB085214, HY352956
    Consensus CDS
    CCDS87547.1
    Related
    ENSP00000419697.1, ENST00000462753.5
    Conserved Domains (1) summary
    pfam09786
    Location:10559
    CytochromB561_N; Cytochrome B561, N terminal
  3. NM_032842.4NP_116231.2  transmembrane protein 209 isoform 1

    See identical proteins and their annotated locations for NP_116231.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087071, AI589217, BC045618
    Consensus CDS
    CCDS47712.1
    UniProtKB/Swiss-Prot
    Q96SK2
    UniProtKB/TrEMBL
    A0A140VJX5
    Related
    ENSP00000380747.2, ENST00000397622.7
    Conserved Domains (1) summary
    pfam09786
    Location:11560
    CytochromB561_N; Cytochrome B561, N terminal

RNA

  1. NR_156699.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC045618, BF930310, HY352956

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    130164713..130205406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250655.2XP_005250712.1  transmembrane protein 209 isoform X1

    See identical proteins and their annotated locations for XP_005250712.1

    UniProtKB/Swiss-Prot
    Q96SK2
    Conserved Domains (1) summary
    pfam09786
    Location:10559
    CytochromB561_N; Cytochrome B561, N terminal
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