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ZNF566 zinc finger protein 566 [ Homo sapiens (human) ]

Gene ID: 84924, updated on 3-Mar-2026
Official Symbol
ZNF566provided by HGNC
Official Full Name
zinc finger protein 566provided by HGNC
Primary source
HGNC:HGNC:25919
See related
Ensembl:ENSG00000186017 AllianceGenome:HGNC:25919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 1.9), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ZNF566 in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36445119..36489561, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39120063..39164789, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36936021..36980463, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZFP82 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36912605-36913287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919277-36919778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919779-36920278 Neighboring gene ACOT4 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:36939953-36941152 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36979559-36980446 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332 Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  4. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14779, MGC12515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 566

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145343.1 → NP_001138815.1  zinc finger protein 566 isoform 2

    See identical proteins and their annotated locations for NP_001138815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting isoform (2) is one amino acid longer than isoform 1.
    Source sequence(s)
    AC092296, DC413210
    Consensus CDS
    CCDS46061.1
    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000400651.2, ENST00000427002.2
    Conserved Domains (6) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:254 → 405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258 → 278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:200 → 222
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001145344.1 → NP_001138816.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092295, AC092296, DC373988
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000411526.2, ENST00000452939.7
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001145345.1 → NP_001138817.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, BC104888, BP351422
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000401259.2, ENST00000424129.7
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001300970.2 → NP_001287899.1  zinc finger protein 566 isoform 3

    See identical proteins and their annotated locations for NP_001287899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC092296, BC104888, BQ269572, DA116442, HY178567
    Consensus CDS
    CCDS74346.1
    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (2) summary
    COG5048
    Location:149 → 300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153 → 173
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001437584.1 → NP_001424513.1  zinc finger protein 566 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092295, AC092296
    Related
    ENSP00000376010.2, ENST00000392170.7

  6. NM_001437585.1 → NP_001424514.1  zinc finger protein 566 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092295, AC092296

  7. NM_001437586.1 → NP_001424515.1  zinc finger protein 566 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092295, AC092296
    UniProtKB/TrEMBL
    B4DRR6
    Related
    ENSP00000465343.1, ENST00000493391.6

  8. NM_001437587.1 → NP_001424516.1  zinc finger protein 566 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092295, AC092296
    UniProtKB/TrEMBL
    B4DRR6

  9. NM_001437588.1 → NP_001424517.1  zinc finger protein 566 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092295, AC092296

  10. NM_032838.4 → NP_116227.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_116227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, AK027685
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    B7ZL95, Q2M3J1, Q969W8
    Related
    ENSP00000415520.2, ENST00000434377.6
    Conserved Domains (6) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:253 → 404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:6 → 45
    KRAB; KRAB box
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36445119..36489561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439566.1 → XP_047295522.1  zinc finger protein 566 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39120063..39164789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322437.1 → XP_054178412.1  zinc finger protein 566 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969W8.1 GenPept UniProtKB/Swiss-Prot:Q969W8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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