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ZNF566 zinc finger protein 566 [ Homo sapiens (human) ]

Gene ID: 84924, updated on 24-Nov-2020

Summary

Official Symbol
ZNF566provided by HGNC
Official Full Name
zinc finger protein 566provided by HGNC
Primary source
HGNC:HGNC:25919
See related
Ensembl:ENSG00000186017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 1.9), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF566 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36445119..36489902, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36936021..36980804, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZFP82 zinc finger protein Neighboring gene acyl-CoA thioesterase 4 pseudogene Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7 Neighboring gene zinc finger protein 260

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14779, MGC12515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145343.1NP_001138815.1  zinc finger protein 566 isoform 2

    See identical proteins and their annotated locations for NP_001138815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting isoform (2) is one amino acid longer than isoform 1.
    Source sequence(s)
    AC092296, DC413210
    Consensus CDS
    CCDS46061.1
    UniProtKB/Swiss-Prot
    Q969W8
    Conserved Domains (6) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:254405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:200222
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:270295
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001145344.1NP_001138816.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092295, AC092296, DC373988
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    Q969W8
    Conserved Domains (6) summary
    smart00349
    Location:665
    KRAB; krueppel associated box
    COG5048
    Location:253404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001145345.1NP_001138817.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_001138817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, BC104888, BP351422
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000401259.2, ENST00000424129.6
    Conserved Domains (6) summary
    smart00349
    Location:665
    KRAB; krueppel associated box
    COG5048
    Location:253404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001300970.2NP_001287899.1  zinc finger protein 566 isoform 3

    See identical proteins and their annotated locations for NP_001287899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC092296, BC104888, BQ269572, DA116442, HY178567
    Consensus CDS
    CCDS74346.1
    UniProtKB/Swiss-Prot
    Q969W8
    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (3) summary
    COG5048
    Location:149300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153173
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:165190
    zf-H2C2_2; Zinc-finger double domain
  5. NM_032838.4NP_116227.1  zinc finger protein 566 isoform 1

    See identical proteins and their annotated locations for NP_116227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC092296, AK027685
    Consensus CDS
    CCDS12494.1
    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000415520.2, ENST00000434377.6
    Conserved Domains (6) summary
    smart00349
    Location:665
    KRAB; krueppel associated box
    COG5048
    Location:253404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199221
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36445119..36489902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527428.1XP_011525730.1  zinc finger protein 566 isoform X3

    See identical proteins and their annotated locations for XP_011525730.1

    UniProtKB/TrEMBL
    B4DRR6
    Related
    ENSP00000465343.1, ENST00000493391.5
    Conserved Domains (3) summary
    COG5048
    Location:149300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153173
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:165190
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027399.1XP_016882888.1  zinc finger protein 566 isoform X3

    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (3) summary
    COG5048
    Location:149300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153173
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:165190
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005259354.2XP_005259411.1  zinc finger protein 566 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:221372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:225245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:167189
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:237262
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005259356.2XP_005259413.1  zinc finger protein 566 isoform X3

    See identical proteins and their annotated locations for XP_005259413.1

    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (3) summary
    COG5048
    Location:149300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153173
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:165190
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006723447.2XP_006723510.1  zinc finger protein 566 isoform X1

    See identical proteins and their annotated locations for XP_006723510.1

    UniProtKB/Swiss-Prot
    Q969W8
    Related
    ENSP00000376010.2, ENST00000392170.6
    Conserved Domains (6) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:254405
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:258278
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:200222
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:270295
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017027400.1XP_016882889.1  zinc finger protein 566 isoform X3

    UniProtKB/TrEMBL
    B4DRR6
    Conserved Domains (3) summary
    COG5048
    Location:149300
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:153173
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:165190
    zf-H2C2_2; Zinc-finger double domain
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