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FIZ1 FLT3 interacting zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 84922, updated on 27-Nov-2024

Summary

Official Symbol
FIZ1provided by HGNC
Official Full Name
FLT3 interacting zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:25917
See related
Ensembl:ENSG00000179943 MIM:609133; AllianceGenome:HGNC:25917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF798
Summary
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 2.2), brain (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

See FIZ1 in Genome Data Viewer
Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55591376..55599517, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58687310..58695453, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56102742..56110883, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene zinc finger protein 579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56115635-56116186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56116187-56116738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11048 Neighboring gene zinc finger protein 524 Neighboring gene zinc finger protein 865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15098

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00416, FLJ14768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
flt3-interacting zinc finger protein 1
Names
zinc finger protein 798

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052830.1 RefSeqGene

    Range
    7454..15595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032836.3NP_116225.2  flt3-interacting zinc finger protein 1

    See identical proteins and their annotated locations for NP_116225.2

    Status: REVIEWED

    Source sequence(s)
    AA864884, AC008735, AK027674, BC132777
    Consensus CDS
    CCDS12928.1
    UniProtKB/Swiss-Prot
    A2RU72, Q6ZMJ7, Q96SL8
    Related
    ENSP00000221665.2, ENST00000221665.5
    Conserved Domains (3) summary
    sd00017
    Location:416436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:470492
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:428453
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55591376..55599517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259352.5XP_005259409.1  flt3-interacting zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005259409.1

    UniProtKB/Swiss-Prot
    A2RU72, Q6ZMJ7, Q96SL8
    Conserved Domains (3) summary
    sd00017
    Location:416436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:470492
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:428453
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047439564.1XP_047295520.1  flt3-interacting zinc finger protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2RU72, Q6ZMJ7, Q96SL8
  3. XM_011527426.3XP_011525728.2  flt3-interacting zinc finger protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58687310..58695453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322432.1XP_054178407.1  flt3-interacting zinc finger protein 1 isoform X1

  2. XM_054322431.1XP_054178406.1  flt3-interacting zinc finger protein 1 isoform X1

  3. XM_054322433.1XP_054178408.1  flt3-interacting zinc finger protein 1 isoform X2