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FAM222A family with sequence similarity 222 member A [ Homo sapiens (human) ]

Gene ID: 84915, updated on 17-Sep-2024

Summary

Official Symbol
FAM222Aprovided by HGNC
Official Full Name
family with sequence similarity 222 member Aprovided by HGNC
Primary source
HGNC:HGNC:25915
See related
Ensembl:ENSG00000139438 AllianceGenome:HGNC:25915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf34
Expression
Broad expression in testis (RPKM 6.4), brain (RPKM 5.9) and 16 other tissues See more
Orthologs
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Genomic context

See FAM222A in Genome Data Viewer
Location:
12q24.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (109713825..109770495)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (109689278..109745953)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110151630..110208300)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110010699-110011200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110011201-110011700 Neighboring gene metabolism of cobalamin associated B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110036333-110037022 Neighboring gene mevalonate kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110049030-110049530 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:110105927-110106096 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:110108888-110110087 Neighboring gene RN7SK pseudogene 250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110133637-110134446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110150092-110150655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110164162-110164872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110169301-110169801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110174581-110175080 Neighboring gene HNF1 motif-containing MPRA enhancer 206 Neighboring gene FAM222A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110177165-110177666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110177667-110178166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110209881-110210380 Neighboring gene Sharpr-MPRA regulatory region 11384 Neighboring gene transient receptor potential cation channel subfamily V member 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110258983-110259483 Neighboring gene uncharacterized LOC105369975 Neighboring gene microRNA 4497

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein FAM222A
Names
aggregatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032829.3NP_116218.2  protein FAM222A

    See identical proteins and their annotated locations for NP_116218.2

    Status: VALIDATED

    Source sequence(s)
    AC007834, BC020193, DN994281
    Consensus CDS
    CCDS9133.1
    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
    Related
    ENSP00000443292.1, ENST00000538780.2
    Conserved Domains (1) summary
    pfam15258
    Location:35235
    FAM222A; Protein family of FAM222A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    109713825..109770495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449229.2XP_024304997.1  protein FAM222A isoform X2

    Conserved Domains (1) summary
    pfam15258
    Location:1201
    FAM222A; Protein family of FAM222A
  2. XM_047429748.1XP_047285704.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
  3. XM_047429749.1XP_047285705.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
  4. XM_017020055.2XP_016875544.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
    Related
    ENSP00000351783.3, ENST00000358906.3
    Conserved Domains (1) summary
    pfam15258
    Location:35235
    FAM222A; Protein family of FAM222A

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    109689278..109745953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373596.1XP_054229571.1  protein FAM222A isoform X2

  2. XM_054373593.1XP_054229568.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
  3. XM_054373594.1XP_054229569.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6
  4. XM_054373595.1XP_054229570.1  protein FAM222A isoform X1

    UniProtKB/Swiss-Prot
    Q5U5X8, Q8NCD5, Q96SP6