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SLC35B4 solute carrier family 35 member B4 [ Homo sapiens (human) ]

Gene ID: 84912, updated on 8-Jul-2021

Summary

Official Symbol
SLC35B4provided by HGNC
Official Full Name
solute carrier family 35 member B4provided by HGNC
Primary source
HGNC:HGNC:20584
See related
Ensembl:ENSG00000205060 MIM:610923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YEA; YEA4
Summary
Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in placenta (RPKM 6.0), brain (RPKM 5.9) and 24 other tissues See more
Orthologs
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Genomic context

See SLC35B4 in Genome Data Viewer
Location:
7q33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (134289332..134320307, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (133974084..134001682, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375513 Neighboring gene uncharacterized LOC105375514 Neighboring gene leucine rich repeats and guanylate kinase domain containing Neighboring gene uncharacterized LOC105375518 Neighboring gene uncharacterized LOC105375517 Neighboring gene uncharacterized LOC105375519

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14697

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UDP-xylose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-xylose and UDP-N-acetylglucosamine transporter
Names
UDP-Xylose/N-Acetylglucosamine transporter
YEA4 homolog
solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032826.5NP_116215.1  UDP-xylose and UDP-N-acetylglucosamine transporter

    See identical proteins and their annotated locations for NP_116215.1

    Status: VALIDATED

    Source sequence(s)
    AB052892, AC008154
    Consensus CDS
    CCDS34756.1
    UniProtKB/Swiss-Prot
    Q969S0
    Related
    ENSP00000367770.4, ENST00000378509.9
    Conserved Domains (1) summary
    pfam08449
    Location:2314
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    134289332..134320307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516645.3XP_011514947.1  UDP-xylose and UDP-N-acetylglucosamine transporter isoform X1

    Conserved Domains (2) summary
    pfam08449
    Location:28314
    UAA; UAA transporter family
    cl23754
    Location:87310
    EamA; EamA-like transporter family

RNA

  1. XR_001744890.2 RNA Sequence

  2. XR_001744888.2 RNA Sequence

  3. XR_001744887.2 RNA Sequence

  4. XR_001744889.2 RNA Sequence

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