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ZNF382 zinc finger protein 382 [ Homo sapiens (human) ]

Gene ID: 84911, updated on 13-May-2022

Summary

Official Symbol
ZNF382provided by HGNC
Official Full Name
zinc finger protein 382provided by HGNC
Primary source
HGNC:HGNC:17409
See related
Ensembl:ENSG00000161298 MIM:609516; AllianceGenome:HGNC:17409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KS1
Summary
This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Expression
Broad expression in brain (RPKM 2.5), testis (RPKM 1.9) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF382 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36605313..36634114)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39280598..39309416)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37096215..37125016)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 260 Neighboring gene zinc finger protein 529 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene zinc finger protein 461 Neighboring gene zinc finger protein 567 Neighboring gene ZNF567 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14686

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 382
Names
KRAB/zinc finger suppressor protein 1
multiple zinc finger and krueppel-associated box protein KS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256838.2NP_001243767.1  zinc finger protein 382 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC074138, AF513816, BC132675, CD690493
    Consensus CDS
    CCDS58659.1
    UniProtKB/Swiss-Prot
    Q96SR6
    Related
    ENSP00000407593.1, ENST00000439428.5
    Conserved Domains (4) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:353532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:309334
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001398490.1NP_001385419.1  zinc finger protein 382 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC074138, AC092295
    Conserved Domains (4) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:354533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:310335
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001398491.1NP_001385420.1  zinc finger protein 382 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC074138, AC092295
    Conserved Domains (4) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:354533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:310335
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001398492.1NP_001385421.1  zinc finger protein 382 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC074138, AC092295
    Conserved Domains (4) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:353532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:309334
    zf-H2C2_2; Zinc-finger double domain
  5. NM_032825.5NP_116214.2  zinc finger protein 382 isoform 1

    See identical proteins and their annotated locations for NP_116214.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC074138, AF513816, CD690493
    Consensus CDS
    CCDS33004.1
    UniProtKB/Swiss-Prot
    Q96SR6
    Related
    ENSP00000292928.2, ENST00000292928.7
    Conserved Domains (4) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:354533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:310335
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36605313..36634114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39280598..39309416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)