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RGS5 regulator of G protein signaling 5 [ Homo sapiens (human) ]

Gene ID: 8490, updated on 17-Dec-2019

Summary

Official Symbol
RGS5provided by HGNC
Official Full Name
regulator of G protein signaling 5provided by HGNC
Primary source
HGNC:HGNC:10001
See related
Ensembl:ENSG00000143248 Ensembl:ENSG00000232995 MIM:603276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
Summary
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]
Expression
Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues See more
Orthologs

Genomic context

See RGS5 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (163142299..163321791, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163112089..163291581, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene regulator of G protein signaling 4 Neighboring gene uncharacterized LOC101928404 Neighboring gene tRNA nucleotidyl transferase 1 pseudogene Neighboring gene NUF2 component of NDC80 kinetochore complex Neighboring gene eukaryotic translation initiation factor 3 subunit J pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Essential hypertension
MedGen: C0085580 OMIM: 145500 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
NHGRI GWA Catalog
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027731.2 RefSeqGene

    Range
    123876..184493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195303.3NP_001182232.1  regulator of G-protein signaling 5 isoform 2

    See identical proteins and their annotated locations for NP_001182232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AJ891044, AL157502, AL583850, BX537427, DA699380
    Consensus CDS
    CCDS55652.1
    UniProtKB/Swiss-Prot
    O15539
    Related
    ENSP00000432313.1, ENST00000527988.1
    Conserved Domains (1) summary
    cl02565
    Location:170
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001254748.1NP_001241677.1  regulator of G-protein signaling 5 isoform 2

    See identical proteins and their annotated locations for NP_001241677.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AL157502, AL583850, BP292867, BX537427, CB991106
    Consensus CDS
    CCDS55652.1
    UniProtKB/Swiss-Prot
    O15539
    Related
    ENSP00000480891.1, ENST00000618415.4
    Conserved Domains (1) summary
    cl02565
    Location:170
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001254749.2NP_001241678.1  regulator of G-protein signaling 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
    Source sequence(s)
    AL157502, AL583850, BU172751, BX537427, DA699380
    Consensus CDS
    CCDS58041.1
    UniProtKB/Swiss-Prot
    O15539
    Related
    ENSP00000433001.1, ENST00000530507.5
    Conserved Domains (1) summary
    cd08717
    Location:65182
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein
  4. NM_003617.4NP_003608.1  regulator of G-protein signaling 5 isoform 1

    See identical proteins and their annotated locations for NP_003608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions.
    Source sequence(s)
    AL451063, AL583850, BC030059
    Consensus CDS
    CCDS1244.1
    UniProtKB/Swiss-Prot
    O15539
    UniProtKB/TrEMBL
    A0A024R8X9
    Related
    ENSP00000319308.5, ENST00000313961.10
    Conserved Domains (1) summary
    cd08717
    Location:65178
    RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein

RNA

  1. NR_045630.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an additional exon in the 5' region and uses alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because it lacks the entire coding region, as found in variants 1-4, and it does not have any alternative supported ORFs.
    Source sequence(s)
    AA805263, BC032239, CB991106
    Related
    ENST00000439699.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    163142299..163321791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025226.1: Suppressed sequence

    Description
    NM_025226.1: This RefSeq was permanently suppressed because it is UTR sequence and contains the wrong CDS.
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