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ATAD1 ATPase family AAA domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84896, updated on 23-Nov-2021

Summary

Official Symbol
ATAD1provided by HGNC
Official Full Name
ATPase family AAA domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25903
See related
Ensembl:ENSG00000138138 MIM:614452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Msp1; AFDC1; HKPX4; FNP001; hATAD1; THORASE
Expression
Ubiquitous expression in testis (RPKM 11.5), heart (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See ATAD1 in Genome Data Viewer
Location:
10q23.31
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (87751512..87841359, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89511269..89577983, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 38 Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene cofilin 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 78, pseudogene Neighboring gene uncharacterized LOC107987150 Neighboring gene killin, p53 regulated DNA replication inhibitor Neighboring gene phosphatase and tensin homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane protein dislocase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in extraction of mislocalized protein from mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane HDA PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
outer mitochondrial transmembrane helix translocase
Names
ATPase family AAA domain-containing protein 1
NP_001308896.1
NP_001308897.1
NP_001308898.1
NP_116199.2
XP_005270309.1
XP_011538604.1
XP_011538605.1
XP_016872336.1
XP_016872337.1
XP_016872338.1
XP_016872339.1
XP_016872340.1
XP_024304010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321967.2NP_001308896.1  outer mitochondrial transmembrane helix translocase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022016, AL133327
    Consensus CDS
    CCDS7386.1
    UniProtKB/Swiss-Prot
    Q8NBU5
    Related
    ENSP00000506333.1, ENST00000680024.1
    Conserved Domains (2) summary
    pfam17862
    Location:282321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
  2. NM_001321968.2NP_001308897.1  outer mitochondrial transmembrane helix translocase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022016, AL133327
    Conserved Domains (2) summary
    pfam17862
    Location:252291
    AAA_lid_3; AAA+ lid domain
    cl38936
    Location:92232
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001321969.2NP_001308898.1  outer mitochondrial transmembrane helix translocase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022016, AL133327
    Conserved Domains (1) summary
    COG0464
    Location:8229
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  4. NM_032810.4NP_116199.2  outer mitochondrial transmembrane helix translocase isoform 1

    See identical proteins and their annotated locations for NP_116199.2

    Status: VALIDATED

    Source sequence(s)
    AC022016, AK075223, AL133327
    Consensus CDS
    CCDS7386.1
    UniProtKB/Swiss-Prot
    Q8NBU5
    Related
    ENSP00000339017.4, ENST00000308448.11
    Conserved Domains (2) summary
    pfam17862
    Location:282321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

RNA

  1. NR_135914.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022016, AL133327
    Related
    ENST00000681308.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    87751512..87841359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270252.5XP_005270309.1  outer mitochondrial transmembrane helix translocase isoform X1

    See identical proteins and their annotated locations for XP_005270309.1

    UniProtKB/Swiss-Prot
    Q8NBU5
    Related
    ENSP00000339016.2, ENST00000328142.3
    Conserved Domains (2) summary
    pfam17862
    Location:282321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
  2. XM_024448242.1XP_024304010.1  outer mitochondrial transmembrane helix translocase isoform X4

    Conserved Domains (1) summary
    COG0464
    Location:8229
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  3. XM_017016847.2XP_016872336.1  outer mitochondrial transmembrane helix translocase isoform X1

    UniProtKB/Swiss-Prot
    Q8NBU5
    Conserved Domains (2) summary
    pfam17862
    Location:282321
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:92257
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
  4. XM_017016850.2XP_016872339.1  outer mitochondrial transmembrane helix translocase isoform X4

    Conserved Domains (1) summary
    COG0464
    Location:8229
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  5. XM_017016848.1XP_016872337.1  outer mitochondrial transmembrane helix translocase isoform X1

    Conserved Domains (2) summary
    pfam17862
    Location:252291
    AAA_lid_3; AAA+ lid domain
    cl38936
    Location:92232
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_017016849.1XP_016872338.1  outer mitochondrial transmembrane helix translocase isoform X4

    Conserved Domains (1) summary
    COG0464
    Location:8229
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  7. XM_011540302.1XP_011538604.1  outer mitochondrial transmembrane helix translocase isoform X2

    See identical proteins and their annotated locations for XP_011538604.1

    Conserved Domains (2) summary
    pfam17862
    Location:224263
    AAA_lid_3; AAA+ lid domain
    cd19520
    Location:34199
    RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
  8. XM_011540303.3XP_011538605.1  outer mitochondrial transmembrane helix translocase isoform X3

    Related
    ENSP00000505894.1, ENST00000680388.1
    Conserved Domains (2) summary
    smart00382
    Location:125254
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:129257
    AAA; ATPase family associated with various cellular activities (AAA)
  9. XM_017016851.2XP_016872340.1  outer mitochondrial transmembrane helix translocase isoform X5

    Related
    ENSP00000505593.1, ENST00000681602.1

RNA

  1. XR_001747245.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171807.1 Reference GRCh38.p13 PATCHES

    Range
    292..34048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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