U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LINGO1 leucine rich repeat and Ig domain containing 1 [ Homo sapiens (human) ]

Gene ID: 84894, updated on 7-Apr-2024

Summary

Official Symbol
LINGO1provided by HGNC
Official Full Name
leucine rich repeat and Ig domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21205
See related
Ensembl:ENSG00000169783 MIM:609791; AllianceGenome:HGNC:21205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LERN1; MRT64; LRRN6A; UNQ201
Summary
Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LINGO1 in Genome Data Viewer
Location:
15q24.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (77613027..77820900, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (75473724..75683106, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (77905369..78113242, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene pseudopodium enriched atypical kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9896 Neighboring gene high mobility group 20A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77787952-77788752 Neighboring gene Sharpr-MPRA regulatory region 2172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77789555-77790354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77799871-77800847 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77801824-77802800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77802801-77803775 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77817641-77818484 Neighboring gene uncharacterized LOC101929457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77819329-77820172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821015-77821858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821859-77822700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77822701-77823544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826181-77826682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826683-77827182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77833845-77834524 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77836028-77836242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77844823-77845466 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77847266-77847858 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77846672-77847265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849047-77849640 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849641-77850232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77857721-77858585 Neighboring gene uncharacterized LOC105370906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863406-77863906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863907-77864407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77866115-77866615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77874268-77874768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77876983-77877794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77892119-77892619 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77893796-77893952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77897574-77898293 Neighboring gene Sharpr-MPRA regulatory region 5143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77903637-77904464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77906671-77907170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77908397-77909223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77913981-77914496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77914497-77915012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77916045-77916560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77922113-77922678 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77926073-77926636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77937918-77938418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77942484-77942984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77952267-77953188 Neighboring gene LINGO1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77959162-77959662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77959663-77960163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77963681-77964597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77969616-77970141 Neighboring gene LINGO1 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78004126-78004664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:78005958-78006458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78029912-78030425 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78031453-78031964 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78031965-78032478 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78032479-78032990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78033504-78034015 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:78039893-78040461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78040462-78041029 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:78041067-78041828 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:78044539-78044736 Neighboring gene MPRA-validated peak2394 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78076600-78077183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78077259-78077760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78090197-78090896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78092471-78092970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78096516-78097110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78100953-78101820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78103235-78103736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78110270-78110904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78110905-78111539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78156801-78157306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78157307-78157812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78161208-78161708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78163573-78164411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78171267-78171767 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78180036-78180778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78196402-78196966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78196967-78197531 Neighboring gene chondroitin sulfate proteoglycan 4 pseudogene 13 Neighboring gene dynamin 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intellectual disability, autosomal recessive 64
MedGen: C4748192 OMIM: 618103 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway.
EBI GWAS Catalog
Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14594, MGC17422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Names
leucine rich repeat neuronal 6A
leucine-rich repeat and immunoglobulin domain-containing protein 1
leucine-rich repeat neuronal protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301186.2NP_001288115.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, DA150164, DA232085
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  2. NM_001301187.2NP_001288116.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, BI669707, DA232085, DA787289
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  3. NM_001301189.2NP_001288118.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AC105133, AK027500, BC011057, BX355455, DA232085, DA494936
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  4. NM_001301191.2NP_001288120.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, BI669707, DA483616
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  5. NM_001301192.2NP_001288121.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, BI669707, DA182630
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  6. NM_001301194.2NP_001288123.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, BI669707, DA525603
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  7. NM_001301195.2NP_001288124.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AC105133, AC110607, AK027500, BC011057, BI825536
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  8. NM_001301197.2NP_001288126.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, DA328735
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  9. NM_001301198.2NP_001288127.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, DB165168
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  10. NM_001301199.2NP_001288128.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, DA410114
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  11. NM_001301200.2NP_001288129.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001288129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.
    Source sequence(s)
    AK027500, BC011057, BC068558, DA183673
    Consensus CDS
    CCDS73766.1
    UniProtKB/Swiss-Prot
    Q96FE5
    Related
    ENSP00000453853.1, ENST00000561030.5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  12. NM_032808.7NP_116197.4  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_116197.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC046168, AK027500, BC011057, BI523562
    Consensus CDS
    CCDS45313.1
    UniProtKB/Swiss-Prot
    D3DW80, Q6NUK3, Q6UXM3, Q6VVG0, Q6VVG1, Q6VVG2, Q8N3K5, Q96FE5, Q96K52
    Related
    ENSP00000347451.6, ENST00000355300.7
    Conserved Domains (6) summary
    TIGR00864
    Location:341421
    PCC; polycystin cation channel protein
    smart00013
    Location:4175
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:66371
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:7396
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:120179
    LRR_8; Leucine rich repeat
    cl11960
    Location:439514
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    77613027..77820900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022682.2XP_016878171.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  2. XM_024450091.2XP_024305859.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  3. XM_011522118.3XP_011520420.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011520420.1

    UniProtKB/Swiss-Prot
    Q96FE5
    Conserved Domains (6) summary
    TIGR00864
    Location:335415
    PCC; polycystin cation channel protein
    smart00013
    Location:3569
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:6790
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:114173
    LRR_8; Leucine rich repeat
    cd20969
    Location:417508
    IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)
    cd21340
    Location:184365
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    75473724..75683106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379006.1XP_054234981.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

  2. XM_054379005.1XP_054234980.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

  3. XM_054379007.1XP_054234982.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1