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ZSCAN10 zinc finger and SCAN domain containing 10 [ Homo sapiens (human) ]

Gene ID: 84891, updated on 23-Nov-2021

Summary

Official Symbol
ZSCAN10provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 10provided by HGNC
Primary source
HGNC:HGNC:12997
See related
Ensembl:ENSG00000130182 MIM:618365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP206; ZNF206
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZSCAN10 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3088890..3099294, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3138891..3149295, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984896 Neighboring gene uncharacterized LOC105371058 Neighboring gene RNA, U1 small nuclear 22, pseudogene Neighboring gene ZNF205 antisense RNA 1 Neighboring gene zinc finger protein 205 Neighboring gene ZNF213 antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 10
Names
zinc finger protein 206

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282415.2NP_001269344.1  zinc finger and SCAN domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001269344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure which results in the use of a downstream in-frame AUG, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK074736, CN366927, CX781288
    Consensus CDS
    CCDS61813.1
    UniProtKB/Swiss-Prot
    Q96SZ4
    Related
    ENSP00000459520.1, ENST00000575108.5
    Conserved Domains (2) summary
    COG5048
    Location:6380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001282416.2NP_001269345.1  zinc finger and SCAN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to variant 1.
    Source sequence(s)
    AC108134, BC114452, CN366927, CX781288, DA729263
    Consensus CDS
    CCDS61814.1
    UniProtKB/Swiss-Prot
    Q96SZ4
    Related
    ENSP00000440047.2, ENST00000538082.5
    Conserved Domains (4) summary
    COG5048
    Location:263637
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:615637
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:428452
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001365272.1NP_001352201.1  zinc finger and SCAN domain-containing protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108134
    Conserved Domains (3) summary
    COG5048
    Location:218592
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:342362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:3132
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  4. NM_001365273.1NP_001352202.1  zinc finger and SCAN domain-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108134
    Conserved Domains (2) summary
    COG5048
    Location:6380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:130150
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_032805.3NP_116194.2  zinc finger and SCAN domain-containing protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC108134, AK027455, BC114452, CN366927, CX781288
    Consensus CDS
    CCDS10493.2
    UniProtKB/Swiss-Prot
    Q96SZ4
    UniProtKB/TrEMBL
    I3L1J3
    Related
    ENSP00000458879.2, ENST00000576985.6
    Conserved Domains (6) summary
    cd07936
    Location:40124
    SCAN; SCAN oligomerization domain
    PHA03418
    Location:156314
    PHA03418; hypothetical E4 protein; Provisional
    COG5048
    Location:400774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:752774
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565589
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3088890..3099294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023792.1XP_016879281.1  zinc finger and SCAN domain-containing protein 10 isoform X2

  2. XM_017023791.1XP_016879280.1  zinc finger and SCAN domain-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    I3L1J3
    Related
    ENSP00000252463.2, ENST00000252463.6
    Conserved Domains (6) summary
    cd07936
    Location:40124
    SCAN; SCAN oligomerization domain
    PHA03418
    Location:156314
    PHA03418; hypothetical E4 protein; Provisional
    COG5048
    Location:400774
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:752774
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565589
    zf-H2C2_2; Zinc-finger double domain
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