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SLC7A3 solute carrier family 7 member 3 [ Homo sapiens (human) ]

Gene ID: 84889, updated on 9-Jun-2020

Summary

Official Symbol
SLC7A3provided by HGNC
Official Full Name
solute carrier family 7 member 3provided by HGNC
Primary source
HGNC:HGNC:11061
See related
Ensembl:ENSG00000165349 MIM:300443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT3; ATRC3; CAT-3
Summary
This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]
Expression
Biased expression in endometrium (RPKM 1.9), prostate (RPKM 1.2) and 8 other tissues See more
Orthologs

Genomic context

See SLC7A3 in Genome Data Viewer
Location:
Xq13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70925579..70931096, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70145429..70150975, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 11 Neighboring gene small nucleolar RNA, C/D box 3E Neighboring gene WASHC3 pseudogene 1 Neighboring gene ribosomal protein S23 pseudogene 8 Neighboring gene nuclear transport factor 2 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14541, MGC20687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-ornithine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-arginine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cationic amino acid transporter 3
Names
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021370.1 RefSeqGene

    Range
    5030..10547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001048164.3NP_001041629.1  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_001041629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075014, BC033816
    Consensus CDS
    CCDS14404.1
    UniProtKB/Swiss-Prot
    Q8WY07
    Related
    ENSP00000298085.4, ENST00000298085.4
    Conserved Domains (2) summary
    TIGR00906
    Location:9591
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:539589
    AA_permease_C; C-terminus of AA_permease
  2. NM_032803.6NP_116192.4  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_116192.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK074865, AL627071, BC033816
    Consensus CDS
    CCDS14404.1
    UniProtKB/Swiss-Prot
    Q8WY07
    Related
    ENSP00000363417.3, ENST00000374299.8
    Conserved Domains (2) summary
    TIGR00906
    Location:9591
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:539589
    AA_permease_C; C-terminus of AA_permease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70925579..70931096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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