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SLC7A3 solute carrier family 7 member 3 [ Homo sapiens (human) ]

Gene ID: 84889, updated on 5-Jul-2025
Official Symbol
SLC7A3provided by HGNC
Official Full Name
solute carrier family 7 member 3provided by HGNC
Primary source
HGNC:HGNC:11061
See related
Ensembl:ENSG00000165349 MIM:300443; AllianceGenome:HGNC:11061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT3; ATRC3; CAT-3
Summary
This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]
Expression
Biased expression in endometrium (RPKM 1.9), prostate (RPKM 1.2) and 8 other tissues See more
Orthologs
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See SLC7A3 in Genome Data Viewer
Location:
Xq13.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70925579..70931096, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (69359629..69365145, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70145429..70150946, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene testis expressed 11 Neighboring gene small nucleolar RNA, C/D box 3E Neighboring gene WASHC3 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70150189-70150690 Neighboring gene ribosomal protein S23 pseudogene 8 Neighboring gene nuclear transport factor 2 pseudogene 7

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ14541, MGC20687

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in L-arginine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-lysine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in L-ornithine import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in ornithine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
cationic amino acid transporter 3
Names
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021370.1 RefSeqGene

    Range
    5030..10547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001048164.3NP_001041629.1  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_001041629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075014, BC033816
    Consensus CDS
    CCDS14404.1
    UniProtKB/Swiss-Prot
    D3DVU7, Q5JQR2, Q8N185, Q8NCA7, Q8WY07, Q96SZ7
    Related
    ENSP00000298085.4, ENST00000298085.4
    Conserved Domains (2) summary
    TIGR00906
    Location:9591
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:539589
    AA_permease_C; C-terminus of AA_permease
  2. NM_032803.6NP_116192.4  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_116192.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK074865, AL627071, BC033816
    Consensus CDS
    CCDS14404.1
    UniProtKB/Swiss-Prot
    D3DVU7, Q5JQR2, Q8N185, Q8NCA7, Q8WY07, Q96SZ7
    Related
    ENSP00000363417.3, ENST00000374299.8
    Conserved Domains (2) summary
    TIGR00906
    Location:9591
    2A0303; cationic amino acid transport permease
    pfam13906
    Location:539589
    AA_permease_C; C-terminus of AA_permease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    70925579..70931096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442598.1XP_047298554.1  cationic amino acid transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    D3DVU7, Q5JQR2, Q8N185, Q8NCA7, Q8WY07, Q96SZ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    69359629..69365145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)