U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZBTB45 zinc finger and BTB domain containing 45 [ Homo sapiens (human) ]

Gene ID: 84878, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZBTB45provided by HGNC
Official Full Name
zinc finger and BTB domain containing 45provided by HGNC
Primary source
HGNC:HGNC:23715
See related
Ensembl:ENSG00000119574 AllianceGenome:HGNC:23715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF499
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 3.6), spleen (RPKM 2.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58513530..58542718, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61609523..61640397, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59024897..59054085, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15206 Neighboring gene solute carrier family 27 member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:59017967-59018180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59023062-59023576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59029424-59030084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59049840-59050470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59050471-59051099 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59054606-59055110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11093 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene Neighboring gene tripartite motif containing 28 Neighboring gene microRNA 6807

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ14486, DKFZp547H249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and BTB domain-containing protein 45
Names
zinc finger protein 499

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316978.2 → NP_001303907.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AC012313, BC024738, DA394169, DA649936
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001316979.2 → NP_001303908.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AK027392, BC024738
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Related
    ENSP00000469089.1, ENST00000594051.6
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001316980.2 → NP_001303909.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC016630, BC024738, HY023937
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001316981.2 → NP_001303910.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AK027392, BC024738, DR158681
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Related
    ENSP00000473072.1, ENST00000600990.1
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001316982.2 → NP_001303911.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    BC024738, DB043101
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

  6. NM_032792.4 → NP_116181.1  zinc finger and BTB domain-containing protein 45

    See identical proteins and their annotated locations for NP_116181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC012313, BC024738, DA649936
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    Related
    ENSP00000346603.2, ENST00000354590.7
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58513530..58542718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723445.4 → XP_006723508.1  zinc finger and BTB domain-containing protein 45 isoform X1

    See identical proteins and their annotated locations for XP_006723508.1

    UniProtKB/Swiss-Prot
    Q96K62
    Conserved Domains (6) summary
    smart00225
    Location:34 → 124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405 → 472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459 → 481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:445 → 470
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61609523..61640397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322426.1 → XP_054178401.1  zinc finger and BTB domain-containing protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q96K62
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96K62.1 GenPept UniProtKB/Swiss-Prot:Q96K62

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous