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ZBTB45 zinc finger and BTB domain containing 45 [ Homo sapiens (human) ]

Gene ID: 84878, updated on 7-Jun-2020

Summary

Official Symbol
ZBTB45provided by HGNC
Official Full Name
zinc finger and BTB domain containing 45provided by HGNC
Primary source
HGNC:HGNC:23715
See related
Ensembl:ENSG00000119574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF499
Expression
Ubiquitous expression in fat (RPKM 3.6), spleen (RPKM 2.9) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB45 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58513530..58542718, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59024897..59031845, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene Neighboring gene uncharacterized LOC105372485 Neighboring gene solute carrier family 27 member 5 Neighboring gene uncharacterized LOC105372486 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene Neighboring gene tripartite motif containing 28 Neighboring gene microRNA 6807

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14486, DKFZp547H249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nervous system development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 45
Names
zinc finger protein 499

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316978.2NP_001303907.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AC012313, BC024738, DA394169, DA649936
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001316979.2NP_001303908.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AK027392, BC024738
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Related
    ENSP00000469089.1, ENST00000594051.6
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001316980.1NP_001303909.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC016630, BC024738, HY023937
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001316981.2NP_001303910.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AK027392, BC024738, DR158681
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Related
    ENSP00000473072.1, ENST00000600990.1
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001316982.1NP_001303911.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    BC024738, DB043101
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
  6. NM_032792.4NP_116181.1  zinc finger and BTB domain-containing protein 45

    See identical proteins and their annotated locations for NP_116181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AC012313, BC024738, DA649936
    Consensus CDS
    CCDS12984.1
    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Related
    ENSP00000346603.2, ENST00000354590.7
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58513530..58542718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723445.3XP_006723508.1  zinc finger and BTB domain-containing protein 45 isoform X1

    See identical proteins and their annotated locations for XP_006723508.1

    UniProtKB/Swiss-Prot
    Q96K62
    UniProtKB/TrEMBL
    A0A024R4T8
    Conserved Domains (6) summary
    smart00225
    Location:34124
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:405472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:459481
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:445470
    zf-H2C2_2; Zinc-finger double domain
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