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ORAI1 ORAI calcium release-activated calcium modulator 1 [ Homo sapiens (human) ]

Gene ID: 84876, updated on 17-Jun-2024

Summary

Official Symbol
ORAI1provided by HGNC
Official Full Name
ORAI calcium release-activated calcium modulator 1provided by HGNC
Primary source
HGNC:HGNC:25896
See related
Ensembl:ENSG00000276045 MIM:610277; AllianceGenome:HGNC:25896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD9; TAM2; ORAT1; CRACM1; TMEM142A
Summary
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in skin (RPKM 16.4), duodenum (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

See ORAI1 in Genome Data Viewer
Location:
12q24.31
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (121626530..121643109)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (121619725..121636322)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122064455..122079946)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene lysine demethylase 2B Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122018218-122019153 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:122020089-122021024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122021025-122021958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122028863-122029678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122029679-122030494 Neighboring gene KDM2B divergent transcript Neighboring gene RNA, U6 small nuclear 1004, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4980 Neighboring gene Sharpr-MPRA regulatory region 5022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122062776-122063276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122070465-122071345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076353-122076870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122076871-122077388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122088979-122089480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122089481-122089980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122101860-122102399 Neighboring gene uncharacterized LOC105370034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122109697-122110623 Neighboring gene MORN repeat containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122124874-122125860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122165743-122166363 Neighboring gene transmembrane protein 120B Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:122194907-122195407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122204395-122204898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:122207988-122208500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4987 Neighboring gene Sharpr-MPRA regulatory region 8824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122216872-122217390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:122217391-122217909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7183 Neighboring gene ras homolog family member F, filopodia associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates ORAI expression in neuron cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium release-activated calcium channel protein 1
Names
calcium release-activated calcium modulator 1
protein orai-1
transmembrane protein 142A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007500.1 RefSeqGene

    Range
    4981..20466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_93

mRNA and Protein(s)

  1. NM_032790.4NP_116179.2  calcium release-activated calcium channel protein 1

    See identical proteins and their annotated locations for NP_116179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele.
    Source sequence(s)
    AC140062, LKPB02000057
    UniProtKB/Swiss-Prot
    Q3MHV3, Q6DHX2, Q96BP7, Q96D31, Q96K71
    Conserved Domains (1) summary
    pfam07856
    Location:73267
    Orai-1; Mediator of CRAC channel activity

RNA

  1. NR_186857.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-protein coding allele.
    Source sequence(s)
    AC140062, KF511472
    Related
    ENST00000646827.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    121626530..121643109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654719.1 Reference GRCh38.p14 PATCHES

    Range
    32306..48880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    121619725..121636322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)