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ORAI1 ORAI calcium release-activated calcium modulator 1 [ Homo sapiens (human) ]

Gene ID: 84876, updated on 24-Nov-2020

Summary

Official Symbol
ORAI1provided by HGNC
Official Full Name
ORAI calcium release-activated calcium modulator 1provided by HGNC
Primary source
HGNC:HGNC:25896
See related
MIM:610277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD9; TAM2; ORAT1; CRACM1; TMEM142A
Summary
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in skin (RPKM 16.4), duodenum (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See ORAI1 in Genome Data Viewer
Location:
12q24.31
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (121626550..121642040)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122064455..122079946)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370033 Neighboring gene KDM2B divergent transcript Neighboring gene RNA, U6 small nuclear 1004, pseudogene Neighboring gene uncharacterized LOC105370034 Neighboring gene MORN repeat containing 3 Neighboring gene transmembrane protein 120B Neighboring gene ras homolog family member F, filopodia associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates ORAI expression in neuron cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
store-operated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
mammary gland epithelium development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
store-operated calcium entry IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium release-activated calcium channel protein 1
Names
calcium release-activated calcium modulator 1
protein orai-1
transmembrane protein 142A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007500.1 RefSeqGene

    Range
    4981..20466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_93

mRNA and Protein(s)

  1. NM_032790.3NP_116179.2  calcium release-activated calcium channel protein 1

    See identical proteins and their annotated locations for NP_116179.2

    Status: REVIEWED

    Source sequence(s)
    AK027372, BC013386, BC075831, BG574128
    UniProtKB/Swiss-Prot
    Q96D31
    UniProtKB/TrEMBL
    A0A024RBT3
    Conserved Domains (1) summary
    pfam07856
    Location:73267
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    121626550..121642040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654719.1 Reference GRCh38.p13 PATCHES

    Range
    32326..47811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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