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PARP10 poly(ADP-ribose) polymerase family member 10 [ Homo sapiens (human) ]

Gene ID: 84875, updated on 13-May-2022

Summary

Official Symbol
PARP10provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 10provided by HGNC
Primary source
HGNC:HGNC:25895
See related
Ensembl:ENSG00000178685 MIM:609564; AllianceGenome:HGNC:25895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD10
Summary
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in spleen (RPKM 25.6), lymph node (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

See PARP10 in Genome Data Viewer
Location:
8q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143977158..144012764, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145135446..145145926, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145051326..145060628, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene plectin Neighboring gene Sharpr-MPRA regulatory region 8265 Neighboring gene uncharacterized LOC124902040 Neighboring gene microRNA 661 Neighboring gene Sharpr-MPRA regulatory region 3935 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene uncharacterized LOC124902039 Neighboring gene sphingomyelin phosphodiesterase 5 (pseudogene) Neighboring gene 5-oxoprolinase, ATP-hydrolysing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14464

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein auto-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein mono-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein mono-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromatin assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral protein processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP10
Names
ADP-ribosyltransferase diphtheria toxin-like 10
poly [ADP-ribose] polymerase 10
NP_001304824.1
NP_116178.2
XP_011515638.1
XP_047278283.1
XP_047278284.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317895.2NP_001304824.1  protein mono-ADP-ribosyltransferase PARP10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains a 5' intron resulting in a distinct 5' UTR and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK303317, BU625932, DC346447
    Consensus CDS
    CCDS83331.1
    UniProtKB/TrEMBL
    B4E0C4, E9PNI7
    Related
    ENSP00000434776.1, ENST00000525773.5
    Conserved Domains (3) summary
    cd01439
    Location:8971016
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12547
    Location:2391
    RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins
    pfam00644
    Location:8321016
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  2. NM_032789.5NP_116178.2  protein mono-ADP-ribosyltransferase PARP10 isoform 1

    See identical proteins and their annotated locations for NP_116178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AK222914, BU625932, DA459446
    Consensus CDS
    CCDS34960.1
    UniProtKB/Swiss-Prot
    Q53GL7
    Related
    ENSP00000325618.7, ENST00000313028.12
    Conserved Domains (4) summary
    cd01439
    Location:8851004
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12547
    Location:1179
    RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins
    pfam00644
    Location:8201004
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl17169
    Location:173245
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_134234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK222914, BC144235, BU625932, DA459446

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143977158..144012764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517336.4XP_011515638.1  protein mono-ADP-ribosyltransferase PARP10 isoform X2

    UniProtKB/TrEMBL
    E9PK67
    Related
    ENSP00000431620.1, ENST00000524918.5
    Conserved Domains (2) summary
    cd01439
    Location:876995
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12547
    Location:1179
    RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins
  2. XM_047422327.1XP_047278283.1  protein mono-ADP-ribosyltransferase PARP10 isoform X1

  3. XM_047422328.1XP_047278284.1  protein mono-ADP-ribosyltransferase PARP10 isoform X3

    Related
    ENSP00000432733.1, ENST00000527262.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145135446..145145926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)